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• W2950785166 abstract "Objective: Limited data was available on the effect of initial blood pressure (BP) index on outcomes in hypertensive octogenarian patients presenting acute myocardial infarction (MI) (AMI) treated with percutaneous coronary intervention (PCI). We aimed to evaluate if initial BP index was predictive for outcomes in hypertensive octogenarian patients treated with PCI for AMI. Design and method: Among 13104 AMI patients who underwent PCI in a nationwide, prospective, and real-world registry (November 2011 - December 2015), 901 hypertensive octogenarian (defined as >80 years) patients without cardiogenic shock were analyzed. The study endpoints were the composite events (cardiac death, non-fatal MI, any revascularization, stroke, or heart failure re-admission) and their components during follow-up. Results: Composite events, all-cause death, and cardiac death occurred in 263 (29.2%), 137 (15.2%), and 101 patients (11.2%), respectively, during a median follow-up of 359 days. The patients in the higher pulse pressure (PP) quartiles had lower rates of composite events, all-cause death, and cardiac death compared with those in the lower PP quartiles. Cox proportional model showed that high initial PP was associated with lower risk of composite events (hazard ratio [HR] 0.987, 95% confidence interval [CI] 0.977–0.998, p = 0.015), all-cause death (HR 0.989, 95% CI 0.978–1.000, p = 0.044), cardiac death (HR 0.981, 95% CI 0.968–0.994, p = 0.004), and non-fatal MI (HR 0.968, 95% CI 0.937–1.000, p = 0.048). In all population and men, compared with the patients with lowest quartiles of PP, those with highest quartiles of PP were independently predictive for fewer composite events. Additionally, on receiver operating characteristic curve analysis, the optimal cutoff value of PP for composite events was 42 mmHg (sensitivity 0.42; specificity 0.70; area under the curve 0.568). Compared to the patients with PP < 42mmHg, those with PP more than 42mmHg had fewer composite events (29.3% vs. 20.4%, HR 0.662, 95% CI 0.503–0.872, p = 0.003). However, systolic BP, diastolic BP, and mean arterial pressure at admission were not associated with any study endpoints. Conclusions: In this study, high initial PP was associated with improved clinical outcomes in hypertensive octogenarian patients with AMI undergoing PCI." @default.
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• W2950785166 date "2019-07-01" @default.
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• W2950785166 title "THE PROGNOSTIC IMPACT OF INITIAL PULSE PRESSURE IN HYPERTENSIVE OCTOGENARIAN PATIENTS PRESENTING ACUTE MYOCARDIAL INFARCTION TREATED WITH PERCUTANEOUS CORONARY INTERVENTION" @default.
• W2950785166 doi "https://doi.org/10.1097/01.hjh.0000573688.49111.e6" @default.
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