FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950789731> ?p ?o ?g. }

• W2950789731 endingPage "2533" @default.
• W2950789731 startingPage "2523" @default.
• W2950789731 abstract "To assess the functional relevance and therapeutic potential of the pro-angiogenic long non-coding RNA MANTIS in vascular disease development.RNA sequencing, CRISPR activation, overexpression, and RNAi demonstrated that MANTIS, especially its Alu-element, limits endothelial ICAM-1 expression in different types of endothelial cells. Loss of MANTIS increased endothelial monocyte adhesion in an ICAM-1-dependent manner. MANTIS reduced the binding of the SWI/SNF chromatin remodelling factor BRG1 at the ICAM-1 promoter. The expression of MANTIS was induced by laminar flow and HMG-CoA-reductase inhibitors (statins) through mechanisms involving epigenetic rearrangements and the transcription factors KLF2 and KLF4. Mutation of the KLF binding motifs in the MANTIS promoter blocked the flow-induced MANTIS expression. Importantly, the expression of MANTIS in human carotid artery endarterectomy material was lower compared with healthy vessels and this effect was prevented by statin therapy. Interestingly, the protective effects of statins were mediated in part through MANTIS, which was required to facilitate the atorvastatin-induced changes in endothelial gene expression. Moreover, the beneficial endothelial effects of statins in culture models (spheroid outgrowth, proliferation, telomerase activity, and vascular organ culture) were lost upon knockdown of MANTIS.MANTIS is tightly regulated by the transcription factors KLF2 and KLF4 and limits the ICAM-1 mediated monocyte adhesion to endothelial cells and thus potentially atherosclerosis development in humans. The beneficial effects of statin treatment and laminar flow are dependent on MANTIS." @default.
• W2950789731 created "2019-06-27" @default.
• W2950789731 creator A5001967997 @default.
• W2950789731 creator A5013946920 @default.
• W2950789731 creator A5016281604 @default.
• W2950789731 creator A5016611690 @default.
• W2950789731 creator A5020736698 @default.
• W2950789731 creator A5033900805 @default.
• W2950789731 creator A5036099552 @default.
• W2950789731 creator A5037576774 @default.
• W2950789731 creator A5038168057 @default.
• W2950789731 creator A5062556449 @default.
• W2950789731 creator A5063786539 @default.
• W2950789731 creator A5070652515 @default.
• W2950789731 creator A5072367499 @default.
• W2950789731 creator A5082251197 @default.
• W2950789731 creator A5086382797 @default.
• W2950789731 creator A5091173895 @default.
• W2950789731 date "2019-06-21" @default.
• W2950789731 modified "2023-10-16" @default.
• W2950789731 title "Pleiotropic effects of laminar flow and statins depend on the Krüppel-like factor-induced lncRNA MANTIS" @default.
• W2950789731 cites W1964220568 @default.
• W2950789731 cites W1968550282 @default.
• W2950789731 cites W1978041309 @default.
• W2950789731 cites W1992067276 @default.
• W2950789731 cites W2001041620 @default.
• W2950789731 cites W2012068657 @default.
• W2950789731 cites W2032033480 @default.
• W2950789731 cites W2092615804 @default.
• W2950789731 cites W2108373798 @default.
• W2950789731 cites W2108868980 @default.
• W2950789731 cites W2110422886 @default.
• W2950789731 cites W2128553106 @default.
• W2950789731 cites W2133546870 @default.
• W2950789731 cites W2135942138 @default.
• W2950789731 cites W2136859326 @default.
• W2950789731 cites W2145276260 @default.
• W2950789731 cites W2145701907 @default.
• W2950789731 cites W2175209522 @default.
• W2950789731 cites W2259938310 @default.
• W2950789731 cites W2519634482 @default.
• W2950789731 cites W2527659978 @default.
• W2950789731 cites W2570787279 @default.
• W2950789731 cites W2587119682 @default.
• W2950789731 cites W2598871689 @default.
• W2950789731 cites W2802334936 @default.
• W2950789731 doi "https://doi.org/10.1093/eurheartj/ehz393" @default.
• W2950789731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31222221" @default.
• W2950789731 hasPublicationYear "2019" @default.
• W2950789731 type Work @default.
• W2950789731 sameAs 2950789731 @default.
• W2950789731 citedByCount "55" @default.
• W2950789731 countsByYear W29507897312019 @default.
• W2950789731 countsByYear W29507897312020 @default.
• W2950789731 countsByYear W29507897312021 @default.
• W2950789731 countsByYear W29507897312022 @default.
• W2950789731 countsByYear W29507897312023 @default.
• W2950789731 crossrefType "journal-article" @default.
• W2950789731 hasAuthorship W2950789731A5001967997 @default.
• W2950789731 hasAuthorship W2950789731A5013946920 @default.
• W2950789731 hasAuthorship W2950789731A5016281604 @default.
• W2950789731 hasAuthorship W2950789731A5016611690 @default.
• W2950789731 hasAuthorship W2950789731A5020736698 @default.
• W2950789731 hasAuthorship W2950789731A5033900805 @default.
• W2950789731 hasAuthorship W2950789731A5036099552 @default.
• W2950789731 hasAuthorship W2950789731A5037576774 @default.
• W2950789731 hasAuthorship W2950789731A5038168057 @default.
• W2950789731 hasAuthorship W2950789731A5062556449 @default.
• W2950789731 hasAuthorship W2950789731A5063786539 @default.
• W2950789731 hasAuthorship W2950789731A5070652515 @default.
• W2950789731 hasAuthorship W2950789731A5072367499 @default.
• W2950789731 hasAuthorship W2950789731A5082251197 @default.
• W2950789731 hasAuthorship W2950789731A5086382797 @default.
• W2950789731 hasAuthorship W2950789731A5091173895 @default.
• W2950789731 hasBestOaLocation W29507897311 @default.
• W2950789731 hasConcept C104317684 @default.
• W2950789731 hasConcept C166703698 @default.
• W2950789731 hasConcept C173396325 @default.
• W2950789731 hasConcept C2777350992 @default.
• W2950789731 hasConcept C54355233 @default.
• W2950789731 hasConcept C67705224 @default.
• W2950789731 hasConcept C71924100 @default.
• W2950789731 hasConcept C86339819 @default.
• W2950789731 hasConcept C86803240 @default.
• W2950789731 hasConcept C95444343 @default.
• W2950789731 hasConceptScore W2950789731C104317684 @default.
• W2950789731 hasConceptScore W2950789731C166703698 @default.
• W2950789731 hasConceptScore W2950789731C173396325 @default.
• W2950789731 hasConceptScore W2950789731C2777350992 @default.
• W2950789731 hasConceptScore W2950789731C54355233 @default.
• W2950789731 hasConceptScore W2950789731C67705224 @default.
• W2950789731 hasConceptScore W2950789731C71924100 @default.
• W2950789731 hasConceptScore W2950789731C86339819 @default.
• W2950789731 hasConceptScore W2950789731C86803240 @default.
• W2950789731 hasConceptScore W2950789731C95444343 @default.
• W2950789731 hasFunder F4320320344 @default.
• W2950789731 hasFunder F4320320879 @default.
• W2950789731 hasFunder F4320321457 @default.

• next