Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950793995> ?p ?o ?g. }
- W2950793995 abstract "Summary Tissue homeostasis requires regulation of cell-cell communication, which relies on signaling molecules and cell contacts. In skin epidermis, keratinocytes secrete specific factors transduced by melanocytes into signaling cues to promote their pigmentation and dendrite outgrowth, while melanocytes transfer melanin pigments to keratinocytes to convey skin photoprotection. How epidermal cells integrate these functions remains poorly characterized. Here, we found that caveolae polarize in melanocytes and are particularly abundant at melanocyte-keratinocyte interface. Caveolae in melanocytes are sensitive to ultra-violet radiations and miRNAs released by keratinocytes. Preventing caveolae formation in melanocytes results in increased production of intracellular cAMP and melanin pigments, but decreases cell protrusions, cell-cell contacts, pigment transfer and epidermis pigmentation. Altogether, our data establish that, in melanocytes, caveolae serve as key molecular hubs that couple signaling outputs from keratinocytes to mechanical plasticity. This process is crucial to maintain cell-cell contacts and intercellular communication, skin pigmentation and tissue homeostasis." @default.
- W2950793995 created "2019-06-27" @default.
- W2950793995 creator A5018471909 @default.
- W2950793995 creator A5023329520 @default.
- W2950793995 creator A5031116181 @default.
- W2950793995 creator A5046961180 @default.
- W2950793995 creator A5047505675 @default.
- W2950793995 creator A5057801626 @default.
- W2950793995 creator A5064098657 @default.
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- W2950793995 creator A5069951920 @default.
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- W2950793995 creator A5075045522 @default.
- W2950793995 creator A5078485909 @default.
- W2950793995 creator A5091734086 @default.
- W2950793995 date "2019-06-10" @default.
- W2950793995 modified "2023-09-26" @default.
- W2950793995 title "Caveolae coupling of melanocytes signaling and mechanics is required for human skin pigmentation" @default.
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