FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950800660> ?p ?o ?g. }

• W2950800660 endingPage "154" @default.
• W2950800660 startingPage "147" @default.
• W2950800660 abstract "Mycobacteria populations can undergo mutations in their DNA sequence during replication, which if not repaired would be transferred to future generations. Earlier studies have tackled the estimation of mutation rate in mycobacteria at fixed concentrations. However, in this study, in vitro spontaneous mutations in Mycobacterium smegmatis (Msm) mc2 155 (Msm) that confers resistance to some of the most important antitubercular drugs; isoniazid (INHr ), rifampicin (RIFr ), kanamycin (KANr ) and streptomycin (STRr ) were first determined at several highly lethal concentrations, a few of which have not been previously investigated, in a fluctuation assay. Thereafter, mutation rate was estimated using the most commonly adopted Po method, and estimates were then compared concurrently with the Lea-Coulson method of the median and Ma-Sandri-Sarkar Maximum Likelihood Estimator method available on the Fluctuation AnaLysis CalculatOR (FALCOR). The mutation rates of RIFr ranged from 9.24 × 10-8 to 2.18 × 10-10 , INHr 1.2 × 10-7 -1.20 × 10-9 , STRr 2.77 × 10-8 -5.31 × 10-8 and KANr 1.7 × 10-8 mutations per cell division. Data obtained in this study provide mutation rate estimates to key antitubercular drugs at a range of concentrations while also validating a number of the frequent approaches for estimating mutation rates." @default.
• W2950800660 created "2019-06-27" @default.
• W2950800660 creator A5017414608 @default.
• W2950800660 date "2018-12-03" @default.
• W2950800660 modified "2023-10-14" @default.
• W2950800660 title "Spontaneous mutations conferring antibiotic resistance to antitubercular drugs at a range of concentrations in<i>Mycobacterium smegmatis</i>" @default.
• W2950800660 cites W1529432107 @default.
• W2950800660 cites W1690968208 @default.
• W2950800660 cites W1821277652 @default.
• W2950800660 cites W1967457339 @default.
• W2950800660 cites W1969870555 @default.
• W2950800660 cites W1970051669 @default.
• W2950800660 cites W1980108230 @default.
• W2950800660 cites W1980304069 @default.
• W2950800660 cites W1987609716 @default.
• W2950800660 cites W2002005215 @default.
• W2950800660 cites W2012977051 @default.
• W2950800660 cites W2013735712 @default.
• W2950800660 cites W2016942897 @default.
• W2950800660 cites W2034254026 @default.
• W2950800660 cites W2055297942 @default.
• W2950800660 cites W2056382779 @default.
• W2950800660 cites W2058925610 @default.
• W2950800660 cites W2068372433 @default.
• W2950800660 cites W2069291592 @default.
• W2950800660 cites W2070413611 @default.
• W2950800660 cites W2075000963 @default.
• W2950800660 cites W2078496572 @default.
• W2950800660 cites W2099982440 @default.
• W2950800660 cites W2107861779 @default.
• W2950800660 cites W2111050722 @default.
• W2950800660 cites W2126621628 @default.
• W2950800660 cites W2129493063 @default.
• W2950800660 cites W2132963724 @default.
• W2950800660 cites W2136085069 @default.
• W2950800660 cites W2140716928 @default.
• W2950800660 cites W2143607548 @default.
• W2950800660 cites W2146216268 @default.
• W2950800660 cites W2153238155 @default.
• W2950800660 cites W2160503977 @default.
• W2950800660 cites W2525480203 @default.
• W2950800660 cites W2751144760 @default.
• W2950800660 cites W2791766014 @default.
• W2950800660 cites W4232794766 @default.
• W2950800660 doi "https://doi.org/10.1002/ddr.21497" @default.
• W2950800660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30511362" @default.
• W2950800660 hasPublicationYear "2018" @default.
• W2950800660 type Work @default.
• W2950800660 sameAs 2950800660 @default.
• W2950800660 citedByCount "7" @default.
• W2950800660 countsByYear W29508006602020 @default.
• W2950800660 countsByYear W29508006602021 @default.
• W2950800660 countsByYear W29508006602022 @default.
• W2950800660 countsByYear W29508006602023 @default.
• W2950800660 crossrefType "journal-article" @default.
• W2950800660 hasAuthorship W2950800660A5017414608 @default.
• W2950800660 hasBestOaLocation W29508006601 @default.
• W2950800660 hasConcept C102306862 @default.
• W2950800660 hasConcept C104317684 @default.
• W2950800660 hasConcept C142724271 @default.
• W2950800660 hasConcept C2775843808 @default.
• W2950800660 hasConcept C2776228421 @default.
• W2950800660 hasConcept C2776448121 @default.
• W2950800660 hasConcept C2776967927 @default.
• W2950800660 hasConcept C2777204207 @default.
• W2950800660 hasConcept C2777975735 @default.
• W2950800660 hasConcept C2778607973 @default.
• W2950800660 hasConcept C2780374374 @default.
• W2950800660 hasConcept C2780920689 @default.
• W2950800660 hasConcept C2781069245 @default.
• W2950800660 hasConcept C501593827 @default.
• W2950800660 hasConcept C501734568 @default.
• W2950800660 hasConcept C523546767 @default.
• W2950800660 hasConcept C54355233 @default.
• W2950800660 hasConcept C71924100 @default.
• W2950800660 hasConcept C86803240 @default.
• W2950800660 hasConcept C89423630 @default.
• W2950800660 hasConcept C98638677 @default.
• W2950800660 hasConceptScore W2950800660C102306862 @default.
• W2950800660 hasConceptScore W2950800660C104317684 @default.
• W2950800660 hasConceptScore W2950800660C142724271 @default.
• W2950800660 hasConceptScore W2950800660C2775843808 @default.
• W2950800660 hasConceptScore W2950800660C2776228421 @default.
• W2950800660 hasConceptScore W2950800660C2776448121 @default.
• W2950800660 hasConceptScore W2950800660C2776967927 @default.
• W2950800660 hasConceptScore W2950800660C2777204207 @default.
• W2950800660 hasConceptScore W2950800660C2777975735 @default.
• W2950800660 hasConceptScore W2950800660C2778607973 @default.
• W2950800660 hasConceptScore W2950800660C2780374374 @default.
• W2950800660 hasConceptScore W2950800660C2780920689 @default.
• W2950800660 hasConceptScore W2950800660C2781069245 @default.
• W2950800660 hasConceptScore W2950800660C501593827 @default.
• W2950800660 hasConceptScore W2950800660C501734568 @default.
• W2950800660 hasConceptScore W2950800660C523546767 @default.
• W2950800660 hasConceptScore W2950800660C54355233 @default.
• W2950800660 hasConceptScore W2950800660C71924100 @default.
• W2950800660 hasConceptScore W2950800660C86803240 @default.
• W2950800660 hasConceptScore W2950800660C89423630 @default.

• next