Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950808206> ?p ?o ?g. }
- W2950808206 abstract "Epigenetic annotation studies of genetic risk variants for multiple sclerosis (MS) implicate dysfunctional lymphocytes in MS susceptibility; however, the role of central nervous system (CNS) cells remains unclear. We investigated the effect of the risk variant, rs7665090G, located near NFKB1, on astrocytes. We demonstrated that chromatin is accessible at the risk locus, a prerequisite for its impact on astroglial function. The risk variant was associated with increased NF-κB signaling and target gene expression, driving lymphocyte recruitment, in cultured human astrocytes and astrocytes within MS lesions, and with increased lesional lymphocytic infiltrates and lesion sizes. Thus, our study establishes a link between genetic risk for MS (rs7665090G) and dysfunctional astrocyte responses associated with increased CNS access for peripheral immune cells. MS may therefore result from variant-driven dysregulation of the peripheral immune system and of the CNS, where perturbed CNS cell function aids in establishing local autoimmune inflammation." @default.
- W2950808206 created "2019-06-27" @default.
- W2950808206 creator A5004216670 @default.
- W2950808206 creator A5015170982 @default.
- W2950808206 creator A5016856927 @default.
- W2950808206 creator A5021896445 @default.
- W2950808206 creator A5023332974 @default.
- W2950808206 creator A5026323775 @default.
- W2950808206 creator A5037690737 @default.
- W2950808206 creator A5039370243 @default.
- W2950808206 creator A5040344297 @default.
- W2950808206 creator A5044658004 @default.
- W2950808206 creator A5057467113 @default.
- W2950808206 creator A5067247686 @default.
- W2950808206 creator A5068241006 @default.
- W2950808206 creator A5076484030 @default.
- W2950808206 date "2018-12-17" @default.
- W2950808206 modified "2023-10-16" @default.
- W2950808206 title "Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis" @default.
- W2950808206 cites W1639462457 @default.
- W2950808206 cites W1860574066 @default.
- W2950808206 cites W1924891590 @default.
- W2950808206 cites W2012785339 @default.
- W2950808206 cites W2018681635 @default.
- W2950808206 cites W2056198580 @default.
- W2950808206 cites W2056958245 @default.
- W2950808206 cites W2058691380 @default.
- W2950808206 cites W2063272984 @default.
- W2950808206 cites W2065029614 @default.
- W2950808206 cites W2078171657 @default.
- W2950808206 cites W2095369231 @default.
- W2950808206 cites W2096791516 @default.
- W2950808206 cites W2099540110 @default.
- W2950808206 cites W2102848905 @default.
- W2950808206 cites W2116053253 @default.
- W2950808206 cites W2117358851 @default.
- W2950808206 cites W2117757143 @default.
- W2950808206 cites W2131307437 @default.
- W2950808206 cites W2135403800 @default.
- W2950808206 cites W2170551349 @default.
- W2950808206 cites W2258027821 @default.
- W2950808206 cites W2259938310 @default.
- W2950808206 cites W2418154035 @default.
- W2950808206 cites W2514448720 @default.
- W2950808206 cites W2565958526 @default.
- W2950808206 cites W2572710398 @default.
- W2950808206 cites W2613180696 @default.
- W2950808206 cites W2619332462 @default.
- W2950808206 cites W2793453767 @default.
- W2950808206 cites W4252639669 @default.
- W2950808206 doi "https://doi.org/10.1038/s41467-018-07785-8" @default.
- W2950808206 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6297228" @default.
- W2950808206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30559390" @default.
- W2950808206 hasPublicationYear "2018" @default.
- W2950808206 type Work @default.
- W2950808206 sameAs 2950808206 @default.
- W2950808206 citedByCount "46" @default.
- W2950808206 countsByYear W29508082062019 @default.
- W2950808206 countsByYear W29508082062020 @default.
- W2950808206 countsByYear W29508082062021 @default.
- W2950808206 countsByYear W29508082062022 @default.
- W2950808206 countsByYear W29508082062023 @default.
- W2950808206 crossrefType "journal-article" @default.
- W2950808206 hasAuthorship W2950808206A5004216670 @default.
- W2950808206 hasAuthorship W2950808206A5015170982 @default.
- W2950808206 hasAuthorship W2950808206A5016856927 @default.
- W2950808206 hasAuthorship W2950808206A5021896445 @default.
- W2950808206 hasAuthorship W2950808206A5023332974 @default.
- W2950808206 hasAuthorship W2950808206A5026323775 @default.
- W2950808206 hasAuthorship W2950808206A5037690737 @default.
- W2950808206 hasAuthorship W2950808206A5039370243 @default.
- W2950808206 hasAuthorship W2950808206A5040344297 @default.
- W2950808206 hasAuthorship W2950808206A5044658004 @default.
- W2950808206 hasAuthorship W2950808206A5057467113 @default.
- W2950808206 hasAuthorship W2950808206A5067247686 @default.
- W2950808206 hasAuthorship W2950808206A5068241006 @default.
- W2950808206 hasAuthorship W2950808206A5076484030 @default.
- W2950808206 hasBestOaLocation W29508082061 @default.
- W2950808206 hasConcept C104317684 @default.
- W2950808206 hasConcept C169760540 @default.
- W2950808206 hasConcept C180754005 @default.
- W2950808206 hasConcept C203014093 @default.
- W2950808206 hasConcept C2776914184 @default.
- W2950808206 hasConcept C2777542381 @default.
- W2950808206 hasConcept C2779830541 @default.
- W2950808206 hasConcept C2780640218 @default.
- W2950808206 hasConcept C41091548 @default.
- W2950808206 hasConcept C529278444 @default.
- W2950808206 hasConcept C54355233 @default.
- W2950808206 hasConcept C84597430 @default.
- W2950808206 hasConcept C86803240 @default.
- W2950808206 hasConcept C8891405 @default.
- W2950808206 hasConceptScore W2950808206C104317684 @default.
- W2950808206 hasConceptScore W2950808206C169760540 @default.
- W2950808206 hasConceptScore W2950808206C180754005 @default.
- W2950808206 hasConceptScore W2950808206C203014093 @default.
- W2950808206 hasConceptScore W2950808206C2776914184 @default.
- W2950808206 hasConceptScore W2950808206C2777542381 @default.
- W2950808206 hasConceptScore W2950808206C2779830541 @default.
- W2950808206 hasConceptScore W2950808206C2780640218 @default.