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- W2950840694 abstract "More than 100 5-substituted thiazolidine-2, 4-diones were prepared and their hypoglycemic and hypolipidemic activities were evaluated with genetically obese and diabetic mice, yellow KK. The structure-activity relationship study showed that the 5-(4-oxybenzyl) moiety is essential for substantial activity. Among these compounds, 5-(4-cyclohexylmethoxy) benzylthiazolidine-2, 4-dione (47), 5-[4-(1-methylcyclohexylmethoxy) benzyl]-thiazolidine-2, 4-dione (49, ADD-3878) and 5-{4-[2-(3-pyridyl) ethoxy] benzyl} thiazolidine-2, 4-dione (59) exhibited the most favorable properties in terms of activity and toxicity." @default.
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- W2950840694 date "1983-05-31" @default.
- W2950840694 modified "2023-09-26" @default.
- W2950840694 title "ChemInform Abstract: STUDIES ON ANTIDIABETIC AGENTS. II. SYNTHESIS OF 5-(4-(1-METHYLCYCLOHEXYLMETHOXY)BENZYL)THIAZOLIDINE-2,4-DIONE (ADD-3878) AND ITS DERIVATIVES." @default.
- W2950840694 cites W1981743642 @default.
- W2950840694 doi "https://doi.org/10.1002/chin.198322243" @default.
- W2950840694 hasPublicationYear "1983" @default.
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