Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950848506> ?p ?o ?g. }
- W2950848506 endingPage "105672" @default.
- W2950848506 startingPage "105672" @default.
- W2950848506 abstract "Metformin is the first line drug in the treatment of type 2 diabetes, however, little is known about its therapeutic potential to prevent or delay damage to the peripheral nerve. Thus, the aim of this study was to investigate whether metformin is able to attenuate the neuroinflammatory response in sciatic nerve of insulin-dependent diabetic mice. Swiss Webster mice were divided into four groups: Control, Diabetic (STZ), Diabetic +100 mg/kg/day of metformin (STZ + M100) and Diabetic +200 mg/kg/day of metformin. Diabetes was induced by streptozotocin (90 mg/kg, i.p.). Only animals with glycemia ≥270 mg/dl were considered diabetics. Metformin prevented atrophy of myelinated axons, and reduced expression of inflammatory mediators (interleukin-1β, inducible nitric oxide synthase and nitric oxide). However, treatment with 200 mg of metformin was more effective in increasing neurotrophic (myelin basic protein and neural growth factor), angiogenic (vascular endothelial growth factor) and anti-inflammatory (inhibitor kappa B-alpha and interleukin 10) factors. Thus, metformin treatment, especially at the dose of 200 mg, protected the nerve from damages related to chronic hyperglycemia." @default.
- W2950848506 created "2019-06-27" @default.
- W2950848506 creator A5004209868 @default.
- W2950848506 creator A5011684851 @default.
- W2950848506 creator A5021835234 @default.
- W2950848506 creator A5023791771 @default.
- W2950848506 creator A5028194390 @default.
- W2950848506 creator A5028210623 @default.
- W2950848506 creator A5045176516 @default.
- W2950848506 creator A5046238443 @default.
- W2950848506 creator A5052885400 @default.
- W2950848506 creator A5065661767 @default.
- W2950848506 creator A5068435142 @default.
- W2950848506 creator A5080724185 @default.
- W2950848506 creator A5081957918 @default.
- W2950848506 date "2019-09-01" @default.
- W2950848506 modified "2023-10-01" @default.
- W2950848506 title "Preventive role of metformin on peripheral neuropathy induced by diabetes" @default.
- W2950848506 cites W1492946553 @default.
- W2950848506 cites W1562556996 @default.
- W2950848506 cites W1604535344 @default.
- W2950848506 cites W1843991022 @default.
- W2950848506 cites W1908628105 @default.
- W2950848506 cites W1909117315 @default.
- W2950848506 cites W1963558935 @default.
- W2950848506 cites W1970596938 @default.
- W2950848506 cites W1974049018 @default.
- W2950848506 cites W1979218365 @default.
- W2950848506 cites W1980356545 @default.
- W2950848506 cites W2003175740 @default.
- W2950848506 cites W2005273684 @default.
- W2950848506 cites W2011960585 @default.
- W2950848506 cites W2015194465 @default.
- W2950848506 cites W2027889563 @default.
- W2950848506 cites W2039718439 @default.
- W2950848506 cites W2066686707 @default.
- W2950848506 cites W2077023300 @default.
- W2950848506 cites W2084998134 @default.
- W2950848506 cites W2096141488 @default.
- W2950848506 cites W2104918241 @default.
- W2950848506 cites W2105713395 @default.
- W2950848506 cites W2115957809 @default.
- W2950848506 cites W2117748926 @default.
- W2950848506 cites W2144283177 @default.
- W2950848506 cites W2157773926 @default.
- W2950848506 cites W2157960189 @default.
- W2950848506 cites W2214755608 @default.
- W2950848506 cites W2339391327 @default.
- W2950848506 cites W2374285893 @default.
- W2950848506 cites W2508596879 @default.
- W2950848506 cites W2512659802 @default.
- W2950848506 cites W2562352605 @default.
- W2950848506 cites W2593319357 @default.
- W2950848506 cites W2597734448 @default.
- W2950848506 cites W2611397450 @default.
- W2950848506 cites W2749206338 @default.
- W2950848506 cites W2790858556 @default.
- W2950848506 cites W2793249329 @default.
- W2950848506 cites W2803334072 @default.
- W2950848506 cites W3006680630 @default.
- W2950848506 cites W4295333450 @default.
- W2950848506 doi "https://doi.org/10.1016/j.intimp.2019.05.057" @default.
- W2950848506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31195189" @default.
- W2950848506 hasPublicationYear "2019" @default.
- W2950848506 type Work @default.
- W2950848506 sameAs 2950848506 @default.
- W2950848506 citedByCount "18" @default.
- W2950848506 countsByYear W29508485062020 @default.
- W2950848506 countsByYear W29508485062021 @default.
- W2950848506 countsByYear W29508485062022 @default.
- W2950848506 countsByYear W29508485062023 @default.
- W2950848506 crossrefType "journal-article" @default.
- W2950848506 hasAuthorship W2950848506A5004209868 @default.
- W2950848506 hasAuthorship W2950848506A5011684851 @default.
- W2950848506 hasAuthorship W2950848506A5021835234 @default.
- W2950848506 hasAuthorship W2950848506A5023791771 @default.
- W2950848506 hasAuthorship W2950848506A5028194390 @default.
- W2950848506 hasAuthorship W2950848506A5028210623 @default.
- W2950848506 hasAuthorship W2950848506A5045176516 @default.
- W2950848506 hasAuthorship W2950848506A5046238443 @default.
- W2950848506 hasAuthorship W2950848506A5052885400 @default.
- W2950848506 hasAuthorship W2950848506A5065661767 @default.
- W2950848506 hasAuthorship W2950848506A5068435142 @default.
- W2950848506 hasAuthorship W2950848506A5080724185 @default.
- W2950848506 hasAuthorship W2950848506A5081957918 @default.
- W2950848506 hasConcept C126322002 @default.
- W2950848506 hasConcept C134018914 @default.
- W2950848506 hasConcept C2777180221 @default.
- W2950848506 hasConcept C2777622882 @default.
- W2950848506 hasConcept C2779178840 @default.
- W2950848506 hasConcept C2779280383 @default.
- W2950848506 hasConcept C2779306644 @default.
- W2950848506 hasConcept C2779901536 @default.
- W2950848506 hasConcept C2780323712 @default.
- W2950848506 hasConcept C519581460 @default.
- W2950848506 hasConcept C555293320 @default.
- W2950848506 hasConcept C71924100 @default.
- W2950848506 hasConcept C98274493 @default.