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- W2950852908 endingPage "351" @default.
- W2950852908 startingPage "337" @default.
- W2950852908 abstract "One of the core diagnostic criteria for Dementia with Lewy Bodies (DLB) is the presence of visual hallucinations. The presence of hallucinations, along with fluctuations in the level of arousal and sleep disturbance, point to potential pathological mechanisms at the level of the thalamus. However, the potential role of thalamic dysfunction in DLB, particularly as it relates to the presence of formed visual hallucinations is not known. Here, we review the literature on the pathophysiology of DLB with respect to modern theories of thalamocortical function and attempt to derive an understanding of how such hallucinations arise. Based on the available literature, we propose that combined thalamic-thalamic reticular nucleus and thalamocortical pathology may explain the phenomenology of visual hallucinations in DLB. In particular, diminished α7 cholinergic activity in the thalamic reticular nucleus may critically disinhibit thalamocortical activity. Further, concentrated pathological changes within the posterior regions of the thalamus may explain the predilection for the hallucinations to be visual in nature." @default.
- W2950852908 created "2019-06-27" @default.
- W2950852908 creator A5008838300 @default.
- W2950852908 creator A5060781519 @default.
- W2950852908 creator A5065692006 @default.
- W2950852908 creator A5086711905 @default.
- W2950852908 creator A5087824793 @default.
- W2950852908 creator A5087833641 @default.
- W2950852908 date "2019-08-01" @default.
- W2950852908 modified "2023-10-18" @default.
- W2950852908 title "Visual hallucinations, thalamocortical physiology and Lewy body disease: A review" @default.
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