Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950868222> ?p ?o ?g. }
- W2950868222 endingPage "33" @default.
- W2950868222 startingPage "26" @default.
- W2950868222 abstract "The thriving field that constitutes cancer metabolism has unveiled some groundbreaking facts over the past two decades, at the heart of which is the TCA cycle and its intermediates. As such and besides its metabolic role, α-ketoglutarate was shown to withstand a wide range of physiological reactions from protection against oxidative stress, collagen and bone maintenance to development and immunity. Most importantly, it constitutes the rate-limiting substrate of 2-oxoglutarate-dependent dioxygenases family enzymes, which are involved in hypoxia sensing and in the shaping of cellular epigenetic landscape, two major drivers of oncogenic transformation. Based on literature reports, we hereby review the benefits of this metabolite as a possible novel adjuvant therapeutic opportunity to target tumor progression. This article is part of the special issue “Mitochondrial metabolic alterations in cancer cells and related therapeutic targets”." @default.
- W2950868222 created "2019-06-27" @default.
- W2950868222 creator A5009635225 @default.
- W2950868222 creator A5011105440 @default.
- W2950868222 creator A5020752451 @default.
- W2950868222 creator A5030285343 @default.
- W2950868222 creator A5056609149 @default.
- W2950868222 date "2020-02-01" @default.
- W2950868222 modified "2023-10-15" @default.
- W2950868222 title "The multifaceted contribution of α-ketoglutarate to tumor progression: An opportunity to exploit?" @default.
- W2950868222 cites W1169286697 @default.
- W2950868222 cites W1485773682 @default.
- W2950868222 cites W1528834211 @default.
- W2950868222 cites W165146914 @default.
- W2950868222 cites W1916910865 @default.
- W2950868222 cites W1964150693 @default.
- W2950868222 cites W1967291345 @default.
- W2950868222 cites W1972382264 @default.
- W2950868222 cites W1979247094 @default.
- W2950868222 cites W1979994693 @default.
- W2950868222 cites W1984882020 @default.
- W2950868222 cites W1988377666 @default.
- W2950868222 cites W1993424454 @default.
- W2950868222 cites W1993672713 @default.
- W2950868222 cites W1995675594 @default.
- W2950868222 cites W1997453048 @default.
- W2950868222 cites W2003336368 @default.
- W2950868222 cites W2004138108 @default.
- W2950868222 cites W2005703314 @default.
- W2950868222 cites W2005729255 @default.
- W2950868222 cites W2008541833 @default.
- W2950868222 cites W2015755329 @default.
- W2950868222 cites W2017075709 @default.
- W2950868222 cites W2021787243 @default.
- W2950868222 cites W2025719835 @default.
- W2950868222 cites W2027419472 @default.
- W2950868222 cites W2028743750 @default.
- W2950868222 cites W2038449573 @default.
- W2950868222 cites W2039295111 @default.
- W2950868222 cites W2044581354 @default.
- W2950868222 cites W2046478443 @default.
- W2950868222 cites W2048216460 @default.
- W2950868222 cites W2051525414 @default.
- W2950868222 cites W2053300826 @default.
- W2950868222 cites W2057199368 @default.
- W2950868222 cites W2058747828 @default.
- W2950868222 cites W2061662711 @default.
- W2950868222 cites W2063673863 @default.
- W2950868222 cites W2064037292 @default.
- W2950868222 cites W2067553186 @default.
- W2950868222 cites W2069024509 @default.
- W2950868222 cites W2069169216 @default.
- W2950868222 cites W2069775190 @default.
- W2950868222 cites W2075826634 @default.
- W2950868222 cites W2076320034 @default.
- W2950868222 cites W2077950462 @default.
- W2950868222 cites W2078972833 @default.
- W2950868222 cites W2080452140 @default.
- W2950868222 cites W2082876469 @default.
- W2950868222 cites W2086557601 @default.
- W2950868222 cites W2087814592 @default.
- W2950868222 cites W2089141914 @default.
- W2950868222 cites W2089461431 @default.
- W2950868222 cites W2089692551 @default.
- W2950868222 cites W2091064407 @default.
- W2950868222 cites W2098273451 @default.
- W2950868222 cites W2102186262 @default.
- W2950868222 cites W2108664872 @default.
- W2950868222 cites W2120553786 @default.
- W2950868222 cites W2126511952 @default.
- W2950868222 cites W2126817554 @default.
- W2950868222 cites W2130503287 @default.
- W2950868222 cites W2130757625 @default.
- W2950868222 cites W2131860315 @default.
- W2950868222 cites W2134061682 @default.
- W2950868222 cites W2134294998 @default.
- W2950868222 cites W2136749294 @default.
- W2950868222 cites W2138872672 @default.
- W2950868222 cites W2140300092 @default.
- W2950868222 cites W2140722007 @default.
- W2950868222 cites W2141871922 @default.
- W2950868222 cites W2149343603 @default.
- W2950868222 cites W2151568543 @default.
- W2950868222 cites W2154313451 @default.
- W2950868222 cites W2157019496 @default.
- W2950868222 cites W2159731673 @default.
- W2950868222 cites W2161130015 @default.
- W2950868222 cites W2164298308 @default.
- W2950868222 cites W2167284343 @default.
- W2950868222 cites W2204695292 @default.
- W2950868222 cites W2254833392 @default.
- W2950868222 cites W2265570171 @default.
- W2950868222 cites W2296652898 @default.
- W2950868222 cites W2344480386 @default.
- W2950868222 cites W2345485999 @default.
- W2950868222 cites W2405506616 @default.
- W2950868222 cites W2413311141 @default.
- W2950868222 cites W2504379340 @default.