FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950872822> ?p ?o ?g. }

• W2950872822 abstract "Background: Both biodegradable and non-biodegradable peptide-loaded implants are already developed for the long-term treatment of patients, thereby reducing the frequency of drug administration. To further improve peptide formulation, extending the scope of implant-based drug delivery systems towards other polymers and processing techniques is highly interesting. Objective: In this study, as a proof-of-principle, the feasibility of hot-melt processing of a peptide active pharmaceutical ingredient was assessed by developing a non-biodegradable poly(ethylenevinyl acetate) (33% VA) implant loaded with 20% (w/w) buserelin acetate. Methods: Cross-sectional implant characterization was performed by Raman microscopy. The stability of buserelin acetate in the polymeric matrix was evaluated for 3 months under ICH stability conditions and the quantity as well as the degradation products analyzed using LC-UV methods. An in vitro dissolution study was performed as well and buserelin acetate and its degradants analyzed using the same chromatographic methods. Results: No significant quantities of buserelin acetate-related degradation products were formed during the hot-melt preparation as well as during the stability study. Together with the consistent buserelin acetate assay values over time, chemical peptide stability was thus demonstrated. The in vitro buserelin acetate release from the implant was found to be diffusion-controlled after an initial burst release, with stable release profiles in the stability study, demonstrating the functional stability of the peptide implant. Conclusion: These results indicate the feasibility of preparing non-biodegradable peptide-loaded implants using the hot-melt production method and may act as a proof of principle concept for further innovation in peptide medicinal formulations." @default.
• W2950872822 created "2019-06-27" @default.
• W2950872822 creator A5010890389 @default.
• W2950872822 creator A5015528105 @default.
• W2950872822 creator A5017615853 @default.
• W2950872822 creator A5025546757 @default.
• W2950872822 creator A5042204494 @default.
• W2950872822 creator A5071470047 @default.
• W2950872822 date "2019-09-16" @default.
• W2950872822 modified "2023-10-17" @default.
• W2950872822 title "Hot-melt Preparation of a Non-biodegradable Peptide Implant: A Proof of Principle" @default.
• W2950872822 cites W143537707 @default.
• W2950872822 cites W1512318310 @default.
• W2950872822 cites W1829247853 @default.
• W2950872822 cites W1970020271 @default.
• W2950872822 cites W1970535534 @default.
• W2950872822 cites W1971669047 @default.
• W2950872822 cites W1977072597 @default.
• W2950872822 cites W1982066269 @default.
• W2950872822 cites W1983473009 @default.
• W2950872822 cites W1985131983 @default.
• W2950872822 cites W1998404051 @default.
• W2950872822 cites W1999501080 @default.
• W2950872822 cites W1999612870 @default.
• W2950872822 cites W2000635193 @default.
• W2950872822 cites W2003286416 @default.
• W2950872822 cites W2004013743 @default.
• W2950872822 cites W2012755298 @default.
• W2950872822 cites W2013142721 @default.
• W2950872822 cites W2018739526 @default.
• W2950872822 cites W2027544406 @default.
• W2950872822 cites W2049507059 @default.
• W2950872822 cites W2055224716 @default.
• W2950872822 cites W2059212524 @default.
• W2950872822 cites W2062030771 @default.
• W2950872822 cites W2072904835 @default.
• W2950872822 cites W2074359547 @default.
• W2950872822 cites W2077173281 @default.
• W2950872822 cites W2077300098 @default.
• W2950872822 cites W2081715284 @default.
• W2950872822 cites W2082025533 @default.
• W2950872822 cites W2085535677 @default.
• W2950872822 cites W2086130473 @default.
• W2950872822 cites W2127065516 @default.
• W2950872822 cites W2131404154 @default.
• W2950872822 cites W2162971220 @default.
• W2950872822 cites W2344598639 @default.
• W2950872822 cites W2745301175 @default.
• W2950872822 cites W2983913035 @default.
• W2950872822 cites W1971261511 @default.
• W2950872822 doi "https://doi.org/10.2174/0929866526666190619113724" @default.
• W2950872822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31215364" @default.
• W2950872822 hasPublicationYear "2019" @default.
• W2950872822 type Work @default.
• W2950872822 sameAs 2950872822 @default.
• W2950872822 citedByCount "0" @default.
• W2950872822 crossrefType "journal-article" @default.
• W2950872822 hasAuthorship W2950872822A5010890389 @default.
• W2950872822 hasAuthorship W2950872822A5015528105 @default.
• W2950872822 hasAuthorship W2950872822A5017615853 @default.
• W2950872822 hasAuthorship W2950872822A5025546757 @default.
• W2950872822 hasAuthorship W2950872822A5042204494 @default.
• W2950872822 hasAuthorship W2950872822A5071470047 @default.
• W2950872822 hasBestOaLocation W29508728222 @default.
• W2950872822 hasConcept C136229726 @default.
• W2950872822 hasConcept C141071460 @default.
• W2950872822 hasConcept C170493617 @default.
• W2950872822 hasConcept C171250308 @default.
• W2950872822 hasConcept C178790620 @default.
• W2950872822 hasConcept C185592680 @default.
• W2950872822 hasConcept C186399102 @default.
• W2950872822 hasConcept C192562407 @default.
• W2950872822 hasConcept C2777230143 @default.
• W2950872822 hasConcept C2778938600 @default.
• W2950872822 hasConcept C2779281246 @default.
• W2950872822 hasConcept C2779820397 @default.
• W2950872822 hasConcept C2779858419 @default.
• W2950872822 hasConcept C2781411149 @default.
• W2950872822 hasConcept C43617362 @default.
• W2950872822 hasConcept C55493867 @default.
• W2950872822 hasConcept C71924100 @default.
• W2950872822 hasConcept C88380143 @default.
• W2950872822 hasConceptScore W2950872822C136229726 @default.
• W2950872822 hasConceptScore W2950872822C141071460 @default.
• W2950872822 hasConceptScore W2950872822C170493617 @default.
• W2950872822 hasConceptScore W2950872822C171250308 @default.
• W2950872822 hasConceptScore W2950872822C178790620 @default.
• W2950872822 hasConceptScore W2950872822C185592680 @default.
• W2950872822 hasConceptScore W2950872822C186399102 @default.
• W2950872822 hasConceptScore W2950872822C192562407 @default.
• W2950872822 hasConceptScore W2950872822C2777230143 @default.
• W2950872822 hasConceptScore W2950872822C2778938600 @default.
• W2950872822 hasConceptScore W2950872822C2779281246 @default.
• W2950872822 hasConceptScore W2950872822C2779820397 @default.
• W2950872822 hasConceptScore W2950872822C2779858419 @default.
• W2950872822 hasConceptScore W2950872822C2781411149 @default.
• W2950872822 hasConceptScore W2950872822C43617362 @default.
• W2950872822 hasConceptScore W2950872822C55493867 @default.
• W2950872822 hasConceptScore W2950872822C71924100 @default.
• W2950872822 hasConceptScore W2950872822C88380143 @default.

• next