FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950874431> ?p ?o ?g. }

• W2950874431 endingPage "654" @default.
• W2950874431 startingPage "644" @default.
• W2950874431 abstract "Type 2 Diabetes Mellitus (T2DM) is reaching epidemic levels worldwide and with it, there is a significant increase in complications associated with the disease. T2DM affects virtually all organ systems including the eye. While frequently overlooked, diabetic keratopathy is the most common ocular complication of diabetes and can manifest in mild to severe forms, the latter of which poses a major threat to vision. As the initial barrier between the environment and the eye, the corneal epithelium functions in innate immune defense. Compromise of this barrier may predispose the cornea to infection and can hinder the refractive capabilities of the eye. The clinical burden in patients with diabetic keratopathy lies primarily in the inability of the corneal epithelium to repair damage and maintain its tight barrier function. Current therapies for diabetic keratopathy are supportive, centering on the prevention of infection and promotion of an optimal healing environment. With no clear disease-modifying agent identified as of yet, a thorough understanding of the pathophysiology that underlies the development of diabetic keratopathy at the cellular level is critical to identify and develop potential therapeutic agents capable of promoting corneal re-epithelialization to accelerate the wound healing process. The focus of this review is to examine what is known regarding the cellular and molecular mechanisms needed to maintain epithelial homeostasis and how it goes awry in diabetes." @default.
• W2950874431 created "2019-06-27" @default.
• W2950874431 creator A5059835142 @default.
• W2950874431 creator A5061241116 @default.
• W2950874431 creator A5087613792 @default.
• W2950874431 date "2019-10-01" @default.
• W2950874431 modified "2023-10-17" @default.
• W2950874431 title "The impact of hyperglycemia on the corneal epithelium: Molecular mechanisms and insight" @default.
• W2950874431 cites W1548369555 @default.
• W2950874431 cites W1558236525 @default.
• W2950874431 cites W1585635925 @default.
• W2950874431 cites W1594856996 @default.
• W2950874431 cites W1596250928 @default.
• W2950874431 cites W1597741096 @default.
• W2950874431 cites W1605910346 @default.
• W2950874431 cites W1615472599 @default.
• W2950874431 cites W1617233045 @default.
• W2950874431 cites W1835811038 @default.
• W2950874431 cites W1962814197 @default.
• W2950874431 cites W1965181383 @default.
• W2950874431 cites W1966621383 @default.
• W2950874431 cites W1967881196 @default.
• W2950874431 cites W1968302298 @default.
• W2950874431 cites W1969408132 @default.
• W2950874431 cites W1970119116 @default.
• W2950874431 cites W1970190670 @default.
• W2950874431 cites W1970301680 @default.
• W2950874431 cites W1971392049 @default.
• W2950874431 cites W1973222840 @default.
• W2950874431 cites W1974961331 @default.
• W2950874431 cites W1975317413 @default.
• W2950874431 cites W1976677664 @default.
• W2950874431 cites W1977644273 @default.
• W2950874431 cites W1978476042 @default.
• W2950874431 cites W1978618464 @default.
• W2950874431 cites W1979224825 @default.
• W2950874431 cites W1982794477 @default.
• W2950874431 cites W1984984255 @default.
• W2950874431 cites W1985188010 @default.
• W2950874431 cites W1986489112 @default.
• W2950874431 cites W1989052059 @default.
• W2950874431 cites W1994979040 @default.
• W2950874431 cites W1998484696 @default.
• W2950874431 cites W1998507169 @default.
• W2950874431 cites W2003514103 @default.
• W2950874431 cites W2003945938 @default.
• W2950874431 cites W2005524979 @default.
• W2950874431 cites W2006875892 @default.
• W2950874431 cites W2007073167 @default.
• W2950874431 cites W2007275305 @default.
• W2950874431 cites W2007414305 @default.
• W2950874431 cites W2011814255 @default.
• W2950874431 cites W2012124754 @default.
• W2950874431 cites W2012796251 @default.
• W2950874431 cites W2013361987 @default.
• W2950874431 cites W2018040137 @default.
• W2950874431 cites W2018585727 @default.
• W2950874431 cites W2022165992 @default.
• W2950874431 cites W2025281085 @default.
• W2950874431 cites W2029388695 @default.
• W2950874431 cites W2032561820 @default.
• W2950874431 cites W2034924100 @default.
• W2950874431 cites W2035343695 @default.
• W2950874431 cites W2037097649 @default.
• W2950874431 cites W2037804585 @default.
• W2950874431 cites W2038198672 @default.
• W2950874431 cites W2040016239 @default.
• W2950874431 cites W2041109111 @default.
• W2950874431 cites W2044401777 @default.
• W2950874431 cites W2049270721 @default.
• W2950874431 cites W2052356702 @default.
• W2950874431 cites W2055371123 @default.
• W2950874431 cites W2060075831 @default.
• W2950874431 cites W2064294492 @default.
• W2950874431 cites W2064523679 @default.
• W2950874431 cites W2070843360 @default.
• W2950874431 cites W2072729614 @default.
• W2950874431 cites W2074154524 @default.
• W2950874431 cites W2074837243 @default.
• W2950874431 cites W2079697174 @default.
• W2950874431 cites W2083227014 @default.
• W2950874431 cites W2085824128 @default.
• W2950874431 cites W2086158336 @default.
• W2950874431 cites W2086667809 @default.
• W2950874431 cites W2094540897 @default.
• W2950874431 cites W2098380862 @default.
• W2950874431 cites W2099280290 @default.
• W2950874431 cites W2101720365 @default.
• W2950874431 cites W2102450673 @default.
• W2950874431 cites W2103245406 @default.
• W2950874431 cites W2103273602 @default.
• W2950874431 cites W2106586766 @default.
• W2950874431 cites W2114949230 @default.
• W2950874431 cites W2116490110 @default.
• W2950874431 cites W2120630795 @default.
• W2950874431 cites W2127497521 @default.
• W2950874431 cites W2130229338 @default.
• W2950874431 cites W2136212424 @default.

• next