FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950883128> ?p ?o ?g. }

• W2950883128 endingPage "e1007408" @default.
• W2950883128 startingPage "e1007408" @default.
• W2950883128 abstract "The mechanisms that ensure fertilization of egg by a sperm are not fully understood. In all teleosts, a channel called the ‘micropyle’ is the only route of entry for sperm to enter and fertilize the egg. The micropyle forms by penetration of the vitelline envelope by a single specialized follicle cell, the micropylar cell. The mechanisms underlying micropylar cell specification and micropyle formation are poorly understood. Here, we show that an effector of the Hippo signaling pathway, the Transcriptional co-activator with a PDZ-binding domain (Taz), plays crucial roles in micropyle formation and fertilization in zebrafish (Danio rerio). Genome editing mutants affecting taz can grow to adults. However, eggs from homozygous taz females are not fertilized even though oocytes in mutant females are histologically normal with intact animal-vegetal polarity, complete meiosis and proper ovulation. We find that taz mutant eggs have no micropyle. Taz protein is specifically enriched in mid-oogenesis in the micropylar cell located at the animal pole of wild type oocyte, where it might regulate the cytoskeleton. Taz protein and micropylar cells are not detected in taz mutant ovaries. Our work identifies a novel role for the Hippo/Taz pathway in micropylar cell specification in zebrafish, and uncovers the molecular basis of micropyle formation in teleosts." @default.
• W2950883128 created "2019-06-27" @default.
• W2950883128 creator A5001501635 @default.
• W2950883128 creator A5007495283 @default.
• W2950883128 creator A5015005766 @default.
• W2950883128 creator A5018972190 @default.
• W2950883128 creator A5027475930 @default.
• W2950883128 creator A5042474150 @default.
• W2950883128 creator A5049713067 @default.
• W2950883128 creator A5061945904 @default.
• W2950883128 creator A5063323250 @default.
• W2950883128 creator A5086358428 @default.
• W2950883128 creator A5089210457 @default.
• W2950883128 date "2019-01-04" @default.
• W2950883128 modified "2023-09-29" @default.
• W2950883128 title "The effector of Hippo signaling, Taz, is required for formation of the micropyle and fertilization in zebrafish" @default.
• W2950883128 cites W1771107213 @default.
• W2950883128 cites W1963272969 @default.
• W2950883128 cites W1966228205 @default.
• W2950883128 cites W1978768517 @default.
• W2950883128 cites W1980380812 @default.
• W2950883128 cites W1980922705 @default.
• W2950883128 cites W1984880871 @default.
• W2950883128 cites W1986851584 @default.
• W2950883128 cites W1993316397 @default.
• W2950883128 cites W1998396050 @default.
• W2950883128 cites W1999536759 @default.
• W2950883128 cites W2001497035 @default.
• W2950883128 cites W2001696735 @default.
• W2950883128 cites W2010707909 @default.
• W2950883128 cites W2020956471 @default.
• W2950883128 cites W2023656723 @default.
• W2950883128 cites W2029018363 @default.
• W2950883128 cites W2044144433 @default.
• W2950883128 cites W2055643392 @default.
• W2950883128 cites W2055912011 @default.
• W2950883128 cites W2056727063 @default.
• W2950883128 cites W2058785354 @default.
• W2950883128 cites W2072565710 @default.
• W2950883128 cites W2094507386 @default.
• W2950883128 cites W2106529708 @default.
• W2950883128 cites W2107449497 @default.
• W2950883128 cites W2112933956 @default.
• W2950883128 cites W2113656660 @default.
• W2950883128 cites W2114281959 @default.
• W2950883128 cites W2122649421 @default.
• W2950883128 cites W2125349610 @default.
• W2950883128 cites W2133007496 @default.
• W2950883128 cites W2146337514 @default.
• W2950883128 cites W2157507475 @default.
• W2950883128 cites W2169110374 @default.
• W2950883128 cites W2223413920 @default.
• W2950883128 cites W2263066329 @default.
• W2950883128 cites W2331747427 @default.
• W2950883128 cites W2474419232 @default.
• W2950883128 cites W2594035655 @default.
• W2950883128 cites W2779183100 @default.
• W2950883128 cites W2782258386 @default.
• W2950883128 cites W2794478094 @default.
• W2950883128 cites W2796538159 @default.
• W2950883128 cites W2800912249 @default.
• W2950883128 cites W2802302382 @default.
• W2950883128 cites W2808222060 @default.
• W2950883128 doi "https://doi.org/10.1371/journal.pgen.1007408" @default.
• W2950883128 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6334976" @default.
• W2950883128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30608921" @default.
• W2950883128 hasPublicationYear "2019" @default.
• W2950883128 type Work @default.
• W2950883128 sameAs 2950883128 @default.
• W2950883128 citedByCount "17" @default.
• W2950883128 countsByYear W29508831282019 @default.
• W2950883128 countsByYear W29508831282020 @default.
• W2950883128 countsByYear W29508831282021 @default.
• W2950883128 countsByYear W29508831282022 @default.
• W2950883128 countsByYear W29508831282023 @default.
• W2950883128 crossrefType "journal-article" @default.
• W2950883128 hasAuthorship W2950883128A5001501635 @default.
• W2950883128 hasAuthorship W2950883128A5007495283 @default.
• W2950883128 hasAuthorship W2950883128A5015005766 @default.
• W2950883128 hasAuthorship W2950883128A5018972190 @default.
• W2950883128 hasAuthorship W2950883128A5027475930 @default.
• W2950883128 hasAuthorship W2950883128A5042474150 @default.
• W2950883128 hasAuthorship W2950883128A5049713067 @default.
• W2950883128 hasAuthorship W2950883128A5061945904 @default.
• W2950883128 hasAuthorship W2950883128A5063323250 @default.
• W2950883128 hasAuthorship W2950883128A5086358428 @default.
• W2950883128 hasAuthorship W2950883128A5089210457 @default.
• W2950883128 hasBestOaLocation W29508831281 @default.
• W2950883128 hasConcept C104317684 @default.
• W2950883128 hasConcept C105702510 @default.
• W2950883128 hasConcept C129536746 @default.
• W2950883128 hasConcept C143065580 @default.
• W2950883128 hasConcept C172512520 @default.
• W2950883128 hasConcept C194058213 @default.
• W2950883128 hasConcept C196843134 @default.
• W2950883128 hasConcept C2776690073 @default.
• W2950883128 hasConcept C2776878037 @default.
• W2950883128 hasConcept C2777095108 @default.

• next