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• W2950888909 abstract "Abstract Objectives Our lab has recently established that the gut microbiota regulates obesity-related vascular dysfunction. However, the specific mechanisms by which the gut microbiota regulates host physiology remain obscure. Indoles are products of bacterial tryptophan metabolism and have been shown to exert various physiological effects on the host. In the current study, we examine the effects of indole-3-propionic acid (IPA) on cardiometabolic outcomes in western diet-fed mice. Methods Male C57BL/6 mice were fed either and standard diet (SD) or western diet (WD) for 5-months (mo). Two additional groups were fed the same diets and supplemented with IPA (SD + IPA and WD + IPA) in autoclaved drinking water (0.1 mg/ml) during the dietary intervention. After 5mo, arterial stiffness was assessed by aortic pulse wave velocity (aPWV). Intestinal permeability was measured with FITC-dextran. Glucose tolerance was assessed after a 6 hour fast followed by intraperitoneal injection of 2 g/kg glucose solution. Results Both WD-fed groups displayed significantly higher body weight than SD and SD + IPA (P < 0.05) with no effect of IPA supplementation. aPWV was significantly higher in WD and WD + IPA compared to SD (485.7 ± 6.7 & 492.8 ± 8.6 vs 436.9 ± 7.0 cm/s, P < 0.05), whereas the SD + IPA was not significantly different than either WD-fed groups (468.1 ± 6.6, P > 0.05). Supplementation with IPA in the SD + IPA group significantly increased glucose AUC compared to SD mice (1763.3 ± 92.0 vs 1397.6 ± 64.0, P < 0.05) and no significant differences were observed with either WD or WD + IPA groups (1623.5 ± 77.3 & 1658.4 ± 88.4, P > 0.05). No significant differences were observed between groups with regard to intestinal permeability. Conclusions In the current study, supplementation with IPA in WD-fed mice did not affect arterial stiffness, glucose tolerance, or intestinal permeability. Future analyses will determine other cardiometabolic effects and characterize the gut microbiota. Funding Sources Colorado Agricultural Experimental Station Research Grant #COL00766." @default.
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• W2950888909 date "2019-06-01" @default.
• W2950888909 modified "2023-10-11" @default.
• W2950888909 title "Cardiometabolic Effects of a Gut Microbial Metabolite of Tryptophan in Western Diet-fed Mice (P21-025-19)" @default.
• W2950888909 doi "https://doi.org/10.1093/cdn/nzz041.p21-025-19" @default.
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