Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950890569> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2950890569 abstract "Abstract Genetic variation in the peptide-binding groove of the highly polymorphic human leukocyte antigen (HLA) class I molecules has repeatedly been associated with HIV-1 control and progression to AIDS, accounting for up to 12% of the variation in HIV-1 set point viral load (spVL). This suggests a key role in disease control for HLA presentation of HIV-1 epitopes to cytotoxic T cells. However, a comprehensive understanding of the relevant HLA-bound HIV epitopes is still elusive. Here we developed a peptidome-wide association study (PepWAS) approach that integrates HLA genotypes and spVL data from 6,311 HIV-infected patients to interrogate the entire HIV-1 proteome (3,252 unique peptides) for disease-relevant peptides. This PepWAS approach revealed a core set of epitopes associated with spVL, including previously characterized epitopes but also several novel disease-relevant peptides. More importantly, each patient presents only 16 (±7) and 6 (±6) of these core epitopes through their individual HLA-B and HLA-A variants, respectively. Differences in these patient-specific epitope repertoires account for almost all the variation in spVL previously associated with HLA genetic variation. PepWAS thus enables a comprehensive functional interpretation of the robust but little understood association between HLA and HIV-1 control, prioritizing a short and targetable list of disease-associated epitopes for personalized immunotherapy." @default.
- W2950890569 created "2019-06-27" @default.
- W2950890569 creator A5004628986 @default.
- W2950890569 creator A5012245890 @default.
- W2950890569 creator A5015541994 @default.
- W2950890569 creator A5019789404 @default.
- W2950890569 creator A5055963963 @default.
- W2950890569 creator A5089009771 @default.
- W2950890569 date "2018-04-24" @default.
- W2950890569 modified "2023-10-02" @default.
- W2950890569 title "HIV Peptidome-Wide Association Study Reveals Patient-Specific Epitope Repertoires Associated with HIV Control" @default.
- W2950890569 cites W1601983824 @default.
- W2950890569 cites W1971302107 @default.
- W2950890569 cites W1984037038 @default.
- W2950890569 cites W1992436001 @default.
- W2950890569 cites W1996464851 @default.
- W2950890569 cites W2000305183 @default.
- W2950890569 cites W2001766969 @default.
- W2950890569 cites W2020097327 @default.
- W2950890569 cites W2028433016 @default.
- W2950890569 cites W2035555649 @default.
- W2950890569 cites W2050944927 @default.
- W2950890569 cites W2064502505 @default.
- W2950890569 cites W2069926681 @default.
- W2950890569 cites W2075906228 @default.
- W2950890569 cites W2088204382 @default.
- W2950890569 cites W2089471930 @default.
- W2950890569 cites W2098951833 @default.
- W2950890569 cites W2101939625 @default.
- W2950890569 cites W2107916366 @default.
- W2950890569 cites W2109130469 @default.
- W2950890569 cites W2111066113 @default.
- W2950890569 cites W2111307685 @default.
- W2950890569 cites W2114068009 @default.
- W2950890569 cites W2123584222 @default.
- W2950890569 cites W2130517250 @default.
- W2950890569 cites W2139833905 @default.
- W2950890569 cites W2142608370 @default.
- W2950890569 cites W2147134928 @default.
- W2950890569 cites W2151651155 @default.
- W2950890569 cites W2154509769 @default.
- W2950890569 cites W2160822369 @default.
- W2950890569 cites W2371536864 @default.
- W2950890569 cites W2404396229 @default.
- W2950890569 cites W2737196618 @default.
- W2950890569 doi "https://doi.org/10.1101/307314" @default.
- W2950890569 hasPublicationYear "2018" @default.
- W2950890569 type Work @default.
- W2950890569 sameAs 2950890569 @default.
- W2950890569 citedByCount "1" @default.
- W2950890569 countsByYear W29508905692021 @default.
- W2950890569 crossrefType "posted-content" @default.
- W2950890569 hasAuthorship W2950890569A5004628986 @default.
- W2950890569 hasAuthorship W2950890569A5012245890 @default.
- W2950890569 hasAuthorship W2950890569A5015541994 @default.
- W2950890569 hasAuthorship W2950890569A5019789404 @default.
- W2950890569 hasAuthorship W2950890569A5055963963 @default.
- W2950890569 hasAuthorship W2950890569A5089009771 @default.
- W2950890569 hasBestOaLocation W29508905691 @default.
- W2950890569 hasConcept C147483822 @default.
- W2950890569 hasConcept C159047783 @default.
- W2950890569 hasConcept C188280979 @default.
- W2950890569 hasConcept C195616568 @default.
- W2950890569 hasConcept C203014093 @default.
- W2950890569 hasConcept C3013748606 @default.
- W2950890569 hasConcept C70721500 @default.
- W2950890569 hasConcept C86803240 @default.
- W2950890569 hasConceptScore W2950890569C147483822 @default.
- W2950890569 hasConceptScore W2950890569C159047783 @default.
- W2950890569 hasConceptScore W2950890569C188280979 @default.
- W2950890569 hasConceptScore W2950890569C195616568 @default.
- W2950890569 hasConceptScore W2950890569C203014093 @default.
- W2950890569 hasConceptScore W2950890569C3013748606 @default.
- W2950890569 hasConceptScore W2950890569C70721500 @default.
- W2950890569 hasConceptScore W2950890569C86803240 @default.
- W2950890569 hasLocation W29508905691 @default.
- W2950890569 hasLocation W29508905692 @default.
- W2950890569 hasOpenAccess W2950890569 @default.
- W2950890569 hasPrimaryLocation W29508905691 @default.
- W2950890569 hasRelatedWork W1558421445 @default.
- W2950890569 hasRelatedWork W1824017900 @default.
- W2950890569 hasRelatedWork W1977258691 @default.
- W2950890569 hasRelatedWork W2001707651 @default.
- W2950890569 hasRelatedWork W2022236080 @default.
- W2950890569 hasRelatedWork W2061096391 @default.
- W2950890569 hasRelatedWork W3094412789 @default.
- W2950890569 hasRelatedWork W4294884133 @default.
- W2950890569 hasRelatedWork W4313355581 @default.
- W2950890569 hasRelatedWork W282463328 @default.
- W2950890569 isParatext "false" @default.
- W2950890569 isRetracted "false" @default.
- W2950890569 magId "2950890569" @default.
- W2950890569 workType "article" @default.