Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950891305> ?p ?o ?g. }
- W2950891305 startingPage "409854" @default.
- W2950891305 abstract "Abstract We previously identified 11 miRNAs which were significantly elevated in blood plasma of pregnant mothers who subsequently gave birth to infants affected by prenatal alcohol exposure (PAE, Heavily Exposed Affected: HEa) compared to those with infants who were exposed but apparently unaffected (Heavily Exposed Unaffected: HEua) or unexposed (UE). These maternal HEamiRNAs were predicted to originate in part, as a paracrine placental signal to influence and coordinate placental epithelial-mesenchymal transition (EMT), a pathway essential for endometrial invasion and development. We now report that PAE inhibits expression of placental EMT pathway members in rodent and primate voluntary alcohol consumption models, with HEamiRNAs collectively mediating placental EMT inhibition. To directly investigate the interaction between HEamiRNAs and ethanol on placenta, we assessed their effects on human placental trophoblast cell lines. When administered together, HEamiRNAs retarded trophoblast cell cycle, significantly impaired expression of core EMT pathway members, and reduced invasiveness, pointing to their collective role in modulating placental growth and invasion deficits seen with PAE. HEamiRNAs additionally interfered with maturation-dependent intracellular calcium dynamics, while promoting syncytialization-dependent increases in placental hormone expression. Finally, a single systemic administration of the pooled murine-expressed HEamiRNA subpopulation, to pregnant mice, decreased fetal and placental growth and inhibited expression of EMT pathway mRNA transcripts in placenta. Taken together, our data suggests that, following PAE, HEamiRNAs interfere with placental development and may contribute to the pathology of Fetal Alcohol Spectrum Disorders." @default.
- W2950891305 created "2019-06-27" @default.
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- W2950891305 date "2018-11-04" @default.
- W2950891305 modified "2023-09-26" @default.
- W2950891305 title "Maternal Pregnancy-Associated Circulating MicroRNA predictors of infant birth outcomes are Determinants of Placental Maturation" @default.
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