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- W2950892708 abstract "Current antibody–drug conjugates (ADCs) suffer from low tissue penetration and significant side effects, largely due to the permanent linkage and/or premature release of cytotoxic payloads. Herein, we developed a prodrug–antibody conjugate (ProADC) strategy by conjugating a bioorthogonal-activatable prodrug with an antibody that allowed on-target release and on-demand activation of cytotoxic drugs at a tumor site. The bioorthogonal-caged prodrug exhibited an enhanced permeability into and on-demand activation within cancer cells, while the pH-sensitive ADC linker allowed on-target release of the anticancer agent. Together, the ProADCs showed enhanced tumor penetration and alleviated side effects for use as an on-target and on-demand chemotherapy agents." @default.
- W2950892708 created "2019-06-27" @default.
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- W2950892708 date "2019-06-01" @default.
- W2950892708 modified "2023-10-09" @default.
- W2950892708 title "Bioorthogonal Prodrug–Antibody Conjugates for On-Target and On-Demand Chemotherapy" @default.
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- W2950892708 doi "https://doi.org/10.31635/ccschem.019.20180038" @default.
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