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• W2950897493 abstract "1 Abstract The human skeleton constantly interacts and adapts to the physical world. We have previously reported that physiologically-relevant mechanical forces lead to small, repairable membrane injuries in bone-forming osteoblasts, resulting in the release of ATP and stimulation of purinergic (P2) calcium responses in neighbouring cells. The goal of this study was to develop a theoretical model describing injury-related ATP and ADP release, extracellular diffusion and degradation, and purinergic responses in neighboring cells. The model was validated using experimental data obtained by measuring intracellular free calcium ([Ca 2+ ] i ) elevations following mechanical stimulation of a single osteoblast. The validated single-cell injury model was then scaled to a tissue-level injury to investigate how purinergic responses communicate information about injuries with varying geometries. We found that total ATP released, peak extracellular ATP concentration and the ADP-mediated signaling component contributed complementary information regarding the mechanical stimulation event. The total amount of ATP released governed the maximal distance from the injury at which purinergic responses were stimulated, as well as the overall number of responders. The peak ATP concentration reflected the severity of an individual cell injury and determined signal propagation velocity and temporal synchrony of responses. Peak ATP concentrations also discriminated between minor and severe injuries that led to the release of similar total amounts of ATP due to differences in injury repair dynamics. The third component was ADP-mediated signaling which became relevant only in larger tissue-level injuries, and it conveyed information about the distance to the injury site and its geometry. Taken together, this study identified specific features of extracellular ATP/ADP spatiotemporal signals that encode the severity of the mechanical stimulus, the distance from the stimulus, as well as the mechano-resilient status of the tissue." @default.
• W2950897493 created "2019-06-27" @default.
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• W2950897493 date "2018-11-06" @default.
• W2950897493 modified "2023-09-26" @default.
• W2950897493 title "Transmission of mechanical information by purinergic signaling" @default.
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• W2950897493 doi "https://doi.org/10.1101/463315" @default.
• W2950897493 hasPublicationYear "2018" @default.
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