FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950902951> ?p ?o ?g. }

• W2950902951 endingPage "830" @default.
• W2950902951 startingPage "830" @default.
• W2950902951 abstract "In critically ill children admitted to pediatric intensive care units (PICUs), enteral nutrition (EN) is often delayed due to gastrointestinal dysfunction or interrupted. Since a macronutrient deficit in these patients has been associated with adverse outcomes in observational studies, supplemental parenteral nutrition (PN) in PICUs has long been widely advised to meeting nutritional requirements. However, uncertainty of timing of initiation, optimal dose and composition of PN has led to a wide variation in previous guidelines and current clinical practices. The PEPaNIC (Early versus Late Parenteral Nutrition in the Pediatric ICU) randomized controlled trial recently showed that withholding PN in the first week in PICUs reduced incidence of new infections and accelerated recovery as compared with providing supplemental PN early (within 24 hours after PICU admission), irrespective of diagnosis, severity of illness, risk of malnutrition or age. The early withholding of amino acids in particular, which are powerful suppressors of intracellular quality control by autophagy, statistically explained this outcome benefit. Importantly, two years after PICU admission, not providing supplemental PN early in PICUs did not negatively affect mortality, growth or health status, and significantly improved neurocognitive development. These findings have an important impact on the recently issued guidelines for PN administration to critically ill children. In this review, we summarize the most recent literature that provides evidence on the implications for clinical practice with regard to the use of early supplemental PN in critically ill children." @default.
• W2950902951 created "2019-06-27" @default.
• W2950902951 creator A5004123840 @default.
• W2950902951 creator A5036267148 @default.
• W2950902951 creator A5042145557 @default.
• W2950902951 creator A5067676046 @default.
• W2950902951 date "2019-06-11" @default.
• W2950902951 modified "2023-10-03" @default.
• W2950902951 title "Early Supplemental Parenteral Nutrition in Critically Ill Children: An Update" @default.
• W2950902951 cites W12481139 @default.
• W2950902951 cites W1854025008 @default.
• W2950902951 cites W1924889160 @default.
• W2950902951 cites W1968213691 @default.
• W2950902951 cites W1981897621 @default.
• W2950902951 cites W1985341884 @default.
• W2950902951 cites W1990957068 @default.
• W2950902951 cites W1992191037 @default.
• W2950902951 cites W2010536286 @default.
• W2950902951 cites W2012740375 @default.
• W2950902951 cites W2015765903 @default.
• W2950902951 cites W2019913746 @default.
• W2950902951 cites W2021512852 @default.
• W2950902951 cites W2022855446 @default.
• W2950902951 cites W2026195583 @default.
• W2950902951 cites W2037007039 @default.
• W2950902951 cites W2044693249 @default.
• W2950902951 cites W2050042549 @default.
• W2950902951 cites W2063433474 @default.
• W2950902951 cites W2065485081 @default.
• W2950902951 cites W2068639024 @default.
• W2950902951 cites W2074200017 @default.
• W2950902951 cites W2079166598 @default.
• W2950902951 cites W2087758209 @default.
• W2950902951 cites W2094069611 @default.
• W2950902951 cites W2097529540 @default.
• W2950902951 cites W2097583135 @default.
• W2950902951 cites W2099458832 @default.
• W2950902951 cites W2108310625 @default.
• W2950902951 cites W2112126701 @default.
• W2950902951 cites W2116690246 @default.
• W2950902951 cites W2124696813 @default.
• W2950902951 cites W2126815059 @default.
• W2950902951 cites W2130090995 @default.
• W2950902951 cites W2148062286 @default.
• W2950902951 cites W2148281700 @default.
• W2950902951 cites W2152541452 @default.
• W2950902951 cites W2153316233 @default.
• W2950902951 cites W2162310928 @default.
• W2950902951 cites W2167620866 @default.
• W2950902951 cites W2173105438 @default.
• W2950902951 cites W2175427460 @default.
• W2950902951 cites W2189331756 @default.
• W2950902951 cites W2201519170 @default.
• W2950902951 cites W2204688376 @default.
• W2950902951 cites W2222150159 @default.
• W2950902951 cites W2290642869 @default.
• W2950902951 cites W2296077201 @default.
• W2950902951 cites W2307805172 @default.
• W2950902951 cites W2331048724 @default.
• W2950902951 cites W2427067217 @default.
• W2950902951 cites W2466059774 @default.
• W2950902951 cites W2502960811 @default.
• W2950902951 cites W2587471669 @default.
• W2950902951 cites W2593461727 @default.
• W2950902951 cites W2616348517 @default.
• W2950902951 cites W2731992384 @default.
• W2950902951 cites W2742122441 @default.
• W2950902951 cites W2766254653 @default.
• W2950902951 cites W2773994657 @default.
• W2950902951 cites W2782826280 @default.
• W2950902951 cites W2788499239 @default.
• W2950902951 cites W2792962897 @default.
• W2950902951 cites W2799862286 @default.
• W2950902951 cites W2801950638 @default.
• W2950902951 cites W2809285559 @default.
• W2950902951 cites W2888259927 @default.
• W2950902951 cites W2889638097 @default.
• W2950902951 cites W2891018315 @default.
• W2950902951 cites W2898483187 @default.
• W2950902951 cites W2919274153 @default.
• W2950902951 cites W3148260032 @default.
• W2950902951 cites W4248055834 @default.
• W2950902951 doi "https://doi.org/10.3390/jcm8060830" @default.
• W2950902951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6616588" @default.
• W2950902951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31212639" @default.
• W2950902951 hasPublicationYear "2019" @default.
• W2950902951 type Work @default.
• W2950902951 sameAs 2950902951 @default.
• W2950902951 citedByCount "9" @default.
• W2950902951 countsByYear W29509029512019 @default.
• W2950902951 countsByYear W29509029512020 @default.
• W2950902951 countsByYear W29509029512021 @default.
• W2950902951 countsByYear W29509029512022 @default.
• W2950902951 countsByYear W29509029512023 @default.
• W2950902951 crossrefType "journal-article" @default.
• W2950902951 hasAuthorship W2950902951A5004123840 @default.
• W2950902951 hasAuthorship W2950902951A5036267148 @default.
• W2950902951 hasAuthorship W2950902951A5042145557 @default.

• next