Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950921141> ?p ?o ?g. }
- W2950921141 endingPage "11774" @default.
- W2950921141 startingPage "11770" @default.
- W2950921141 abstract "A novel dynamic kinetic resolution (DKR) of tetrasubstituted alkenyl cyanohydrins prepared from the corresponding α,β-unsaturated aldehydes is described. The deprotonation of a geometrical mixture of tetrasubstituted alkenyl cyanohydrins with sodium diisopropylamide (NaDA) affords the allylic anions, which enables the equilibration of the E- and Z-olefins to permit the selective functionalization of the E-adduct. Theoretical studies indicate that the nature of the alkali metal cation is a critical component to lowering the barrier for interconversion between the two geometrical isomers, which provides the mechanistic basis for the DKR reaction. In addition, we demonstrate that the DKR reaction can be combined with a transition metal-catalyzed allylic substitution to generate a stereodefined E-tetrasubstituted olefin and quaternary center in a single cross-coupling reaction." @default.
- W2950921141 created "2019-06-27" @default.
- W2950921141 creator A5002278047 @default.
- W2950921141 creator A5007358806 @default.
- W2950921141 creator A5030203661 @default.
- W2950921141 creator A5035705415 @default.
- W2950921141 creator A5036451127 @default.
- W2950921141 creator A5058726532 @default.
- W2950921141 date "2019-06-10" @default.
- W2950921141 modified "2023-10-14" @default.
- W2950921141 title "Dynamic Kinetic Resolution of Alkenyl Cyanohydrins Derived from α,β-Unsaturated Aldehydes: Stereoselective Synthesis of <i>E</i>-Tetrasubstituted Olefins" @default.
- W2950921141 cites W1133479866 @default.
- W2950921141 cites W1589885152 @default.
- W2950921141 cites W163432027 @default.
- W2950921141 cites W1946387153 @default.
- W2950921141 cites W1967577393 @default.
- W2950921141 cites W1969913866 @default.
- W2950921141 cites W1976233610 @default.
- W2950921141 cites W1978717953 @default.
- W2950921141 cites W1983586859 @default.
- W2950921141 cites W1984780201 @default.
- W2950921141 cites W1986649141 @default.
- W2950921141 cites W2009080009 @default.
- W2950921141 cites W2012078286 @default.
- W2950921141 cites W2014987264 @default.
- W2950921141 cites W2036885659 @default.
- W2950921141 cites W2042655645 @default.
- W2950921141 cites W2043935388 @default.
- W2950921141 cites W2064220822 @default.
- W2950921141 cites W2074808135 @default.
- W2950921141 cites W2079050104 @default.
- W2950921141 cites W2092753566 @default.
- W2950921141 cites W2124174012 @default.
- W2950921141 cites W2141349182 @default.
- W2950921141 cites W2169499342 @default.
- W2950921141 cites W2179317852 @default.
- W2950921141 cites W2223437988 @default.
- W2950921141 cites W2283198005 @default.
- W2950921141 cites W2314049701 @default.
- W2950921141 cites W2315195728 @default.
- W2950921141 cites W2315886424 @default.
- W2950921141 cites W2324835515 @default.
- W2950921141 cites W2343005526 @default.
- W2950921141 cites W2463638842 @default.
- W2950921141 cites W2466466163 @default.
- W2950921141 cites W2498545966 @default.
- W2950921141 cites W2531191053 @default.
- W2950921141 cites W2531541872 @default.
- W2950921141 cites W2575636094 @default.
- W2950921141 cites W2587433337 @default.
- W2950921141 cites W2604138798 @default.
- W2950921141 cites W2616346225 @default.
- W2950921141 cites W2734882627 @default.
- W2950921141 cites W2742321539 @default.
- W2950921141 cites W2744902780 @default.
- W2950921141 cites W2752497817 @default.
- W2950921141 cites W2767240464 @default.
- W2950921141 cites W2767378364 @default.
- W2950921141 cites W2768387027 @default.
- W2950921141 cites W2791885784 @default.
- W2950921141 cites W2803127873 @default.
- W2950921141 cites W2803788565 @default.
- W2950921141 cites W2900879334 @default.
- W2950921141 cites W2951079330 @default.
- W2950921141 cites W2951679738 @default.
- W2950921141 cites W4230392976 @default.
- W2950921141 cites W4301682897 @default.
- W2950921141 doi "https://doi.org/10.1021/jacs.9b04384" @default.
- W2950921141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31180679" @default.
- W2950921141 hasPublicationYear "2019" @default.
- W2950921141 type Work @default.
- W2950921141 sameAs 2950921141 @default.
- W2950921141 citedByCount "11" @default.
- W2950921141 countsByYear W29509211412020 @default.
- W2950921141 countsByYear W29509211412021 @default.
- W2950921141 countsByYear W29509211412022 @default.
- W2950921141 countsByYear W29509211412023 @default.
- W2950921141 crossrefType "journal-article" @default.
- W2950921141 hasAuthorship W2950921141A5002278047 @default.
- W2950921141 hasAuthorship W2950921141A5007358806 @default.
- W2950921141 hasAuthorship W2950921141A5030203661 @default.
- W2950921141 hasAuthorship W2950921141A5035705415 @default.
- W2950921141 hasAuthorship W2950921141A5036451127 @default.
- W2950921141 hasAuthorship W2950921141A5058726532 @default.
- W2950921141 hasConcept C118629725 @default.
- W2950921141 hasConcept C120095180 @default.
- W2950921141 hasConcept C145148216 @default.
- W2950921141 hasConcept C146686406 @default.
- W2950921141 hasConcept C161790260 @default.
- W2950921141 hasConcept C178790620 @default.
- W2950921141 hasConcept C181647583 @default.
- W2950921141 hasConcept C185592680 @default.
- W2950921141 hasConcept C28173026 @default.
- W2950921141 hasConcept C51886252 @default.
- W2950921141 hasConcept C71240020 @default.
- W2950921141 hasConceptScore W2950921141C118629725 @default.
- W2950921141 hasConceptScore W2950921141C120095180 @default.
- W2950921141 hasConceptScore W2950921141C145148216 @default.