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- W2950926073 abstract "In mammalian cells, the decision to maintain quiescence over proliferation commitment during G 1 ‐S transition depends on more than one intertwined feedback interaction and is highly cell‐type dependent. However, the precise role played by these individual feedback regulations in organizing such diverse proliferation dynamics is still poorly understood. Herein, we propose a predictive mathematical model of G 1 ‐S transition in mammalian cells that reconciles distinct single‐cell experimental observations in a cell‐type specific manner. The model analysis reveals that the feedback motifs responsible for the G 1 ‐S transition act in a disparate fashion to organize the cell‐type specific proliferation response. Importantly, the proposed model can be effectively tuned to gain insights into the proliferation commitment of diverse mammalian cell types and can find wide applicability." @default.
- W2950926073 created "2019-06-27" @default.
- W2950926073 creator A5008114894 @default.
- W2950926073 creator A5069111230 @default.
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- W2950926073 date "2018-09-21" @default.
- W2950926073 modified "2023-10-06" @default.
- W2950926073 title "Disproportionate feedback interactions govern cell‐type specific proliferation in mammalian cells" @default.
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- W2950926073 doi "https://doi.org/10.1002/1873-3468.13241" @default.
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