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- W2950931747 abstract "Abstract The intron-lariat spliceosome (ILS) complex is highly conserved among eukaryotes, and its disassembly marks the end of a canonical splicing cycle. In this study, we show that two conserved disassembly factors of the ILS complex, Increased Level of Polyploidy1-1D (ILP1) and NTC-Related protein 1 (NTR1), positively regulate microRNA (miRNA) biogenesis by facilitating transcriptional elongation of MIRNA (MIR) genes in Arabidopsis thaliana. ILP1 and NTR1 formed a stable complex and co-regulated alternative splicing of more than a hundred genes across the Arabidopsis genome, including some primary transcripts of miRNAs (pri-miRNAs). Intriguingly, pri-miRNAs, regardless of having introns or not, were globally down-regulated when the ILP1 or NTR1 function was compromised. ILP1 and NTR1 interacted with core miRNA processing proteins Dicer-like 1 and Serrate, and were required for proper RNA polymerase II occupancy at elongated regions of MIR chromatin, without affecting either MIR promoter activity or pri-miRNA decay. Our results provide further insights into the regulatory role of spliceosomal machineries in the biogenesis of miRNAs." @default.
- W2950931747 created "2019-06-27" @default.
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- W2950931747 date "2019-06-19" @default.
- W2950931747 modified "2023-10-17" @default.
- W2950931747 title "Spliceosome disassembly factors ILP1 and NTR1 promote miRNA biogenesis in Arabidopsis thaliana" @default.
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- W2950931747 doi "https://doi.org/10.1093/nar/gkz526" @default.
- W2950931747 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6736097" @default.
- W2950931747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31216029" @default.
- W2950931747 hasPublicationYear "2019" @default.