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- W2950935017 abstract "Abstract From the studies on the innate and adaptive immune response of the oral mucosa, experiments have been initiated on the use of the sublingual route in the administration, absorption and immunization of a vaccine against the human influenza virus. Unlike intranasal administration, the sublingual route is effective and safe and does not redirect the antigen or adjuvant to the central nervous system. The first studies conducted with soluble proteins from the influenza A virus associated with an adjuvant showed that they induced a broad and intense immune response in all mucous membranes and extramucosal tissues, including the production of secretory (IgA-s) and non-secretory (IgG) antibodies, systemic immunity and response in specific cytotoxic T lymphocytes (Th1 and Th2). Different studies have shown that the sublingual immune response is equally effective if other antigenic presentations are used (M2 protein, recombinant vectors or attenuated virus). The ease of administration by this route, either in its liquid presentation or in tablets, would facilitate the acceptability and adhesion of the population, especially children, to the vaccination of the entire population against influenza." @default.
- W2950935017 created "2019-06-27" @default.
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- W2950935017 date "2019-01-01" @default.
- W2950935017 modified "2023-10-03" @default.
- W2950935017 title "The sublingual influenza vaccine" @default.
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- W2950935017 doi "https://doi.org/10.1016/j.vacune.2018.10.002" @default.
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