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- W2950938052 endingPage "e1007767" @default.
- W2950938052 startingPage "e1007767" @default.
- W2950938052 abstract "Behavior and physiology are orchestrated by neuropeptides acting as central neuromodulators and circulating hormones. An outstanding question is how these neuropeptides function to coordinate complex and competing behaviors. In Drosophila, the neuropeptide leucokinin (LK) modulates diverse functions, but mechanisms underlying these complex interactions remain poorly understood. As a first step towards understanding these mechanisms, we delineated LK circuitry that governs various aspects of post-feeding physiology and behavior. We found that impaired LK signaling in Lk and Lk receptor (Lkr) mutants affects diverse but coordinated processes, including regulation of stress, water homeostasis, feeding, locomotor activity, and metabolic rate. Next, we sought to define the populations of LK neurons that contribute to the different aspects of this physiology. We find that the calcium activity in abdominal ganglia LK neurons (ABLKs), but not in the two sets of brain neurons, increases specifically following water consumption, suggesting that ABLKs regulate water homeostasis and its associated physiology. To identify targets of LK peptide, we mapped the distribution of Lkr expression, mined a brain single-cell transcriptome dataset for genes coexpressed with Lkr, and identified synaptic partners of LK neurons. Lkr expression in the brain insulin-producing cells (IPCs), gut, renal tubules and chemosensory cells, correlates well with regulatory roles detected in the Lk and Lkr mutants. Furthermore, these mutants and flies with targeted knockdown of Lkr in IPCs displayed altered expression of insulin-like peptides (DILPs) and transcripts in IPCs and increased starvation resistance. Thus, some effects of LK signaling appear to occur via DILP action. Collectively, our data suggest that the three sets of LK neurons have different targets, but modulate the establishment of post-prandial homeostasis by regulating distinct physiological processes and behaviors such as diuresis, metabolism, organismal activity and insulin signaling. These findings provide a platform for investigating feeding-related neuroendocrine regulation of vital behavior and physiology." @default.
- W2950938052 created "2019-06-27" @default.
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- W2950938052 date "2018-11-20" @default.
- W2950938052 modified "2023-10-05" @default.
- W2950938052 title "Modulation of Drosophila post-feeding physiology and behavior by the neuropeptide leucokinin" @default.
- W2950938052 cites W1580426270 @default.
- W2950938052 cites W1677736314 @default.
- W2950938052 cites W1805974357 @default.
- W2950938052 cites W1898922522 @default.
- W2950938052 cites W1963958842 @default.
- W2950938052 cites W1968358311 @default.
- W2950938052 cites W1968931484 @default.
- W2950938052 cites W1972897139 @default.
- W2950938052 cites W1975143118 @default.
- W2950938052 cites W1976699806 @default.
- W2950938052 cites W1978157456 @default.
- W2950938052 cites W1981505811 @default.
- W2950938052 cites W1983706834 @default.
- W2950938052 cites W1984400210 @default.
- W2950938052 cites W1985368535 @default.
- W2950938052 cites W1987692590 @default.
- W2950938052 cites W1987870392 @default.
- W2950938052 cites W1987942547 @default.
- W2950938052 cites W1993445706 @default.
- W2950938052 cites W1993827187 @default.
- W2950938052 cites W2005923152 @default.
- W2950938052 cites W2006641069 @default.
- W2950938052 cites W2011646214 @default.
- W2950938052 cites W2018368316 @default.
- W2950938052 cites W2021892293 @default.
- W2950938052 cites W2022374483 @default.
- W2950938052 cites W2025654941 @default.
- W2950938052 cites W2029166453 @default.
- W2950938052 cites W2030116088 @default.
- W2950938052 cites W2030439009 @default.
- W2950938052 cites W2035208962 @default.
- W2950938052 cites W2035569932 @default.
- W2950938052 cites W2035959740 @default.
- W2950938052 cites W2039278637 @default.
- W2950938052 cites W2040570333 @default.
- W2950938052 cites W2040900811 @default.
- W2950938052 cites W2049725370 @default.
- W2950938052 cites W2050726902 @default.
- W2950938052 cites W2053983287 @default.
- W2950938052 cites W2070283619 @default.
- W2950938052 cites W2076785505 @default.
- W2950938052 cites W2091281002 @default.
- W2950938052 cites W2107900138 @default.
- W2950938052 cites W2114570000 @default.
- W2950938052 cites W2130294546 @default.
- W2950938052 cites W2133745958 @default.
- W2950938052 cites W2135751988 @default.
- W2950938052 cites W2141830087 @default.
- W2950938052 cites W2157765869 @default.
- W2950938052 cites W2162253314 @default.
- W2950938052 cites W2162725445 @default.
- W2950938052 cites W2162910538 @default.
- W2950938052 cites W2167061161 @default.
- W2950938052 cites W2167279371 @default.
- W2950938052 cites W2268896030 @default.
- W2950938052 cites W2284531539 @default.
- W2950938052 cites W2290000470 @default.
- W2950938052 cites W2290373952 @default.
- W2950938052 cites W2303447128 @default.
- W2950938052 cites W2335651339 @default.
- W2950938052 cites W2361741925 @default.
- W2950938052 cites W2548707539 @default.
- W2950938052 cites W2549162961 @default.
- W2950938052 cites W2735863355 @default.
- W2950938052 cites W2765562046 @default.
- W2950938052 cites W2790386501 @default.
- W2950938052 cites W2807884764 @default.
- W2950938052 cites W2950404890 @default.
- W2950938052 cites W2952723908 @default.
- W2950938052 cites W2952739011 @default.
- W2950938052 cites W2952912187 @default.
- W2950938052 doi "https://doi.org/10.1371/journal.pgen.1007767" @default.
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- W2950938052 hasPublicationYear "2018" @default.
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