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• W2950939912 abstract "A novel approach for the synthesis of Crizotinib (1) is described. In addition, new efficient procedures have been developed for the preparation of (S)-1-(2,6-dichloro-3-fluorophenyl)ethanol (2) and tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (4), the key intermediates required for the synthesis of Crizotinib." @default.
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• W2950939912 date "2014-02-01" @default.
• W2950939912 modified "2023-10-14" @default.
• W2950939912 title "A novel approach for the synthesis of Crizotinib through the key chiral alcohol intermediate by asymmetric hydrogenation using highly active Ir-Spiro-PAP catalyst" @default.
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• W2950939912 doi "https://doi.org/10.1016/j.tetlet.2014.01.053" @default.
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