FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950951682> ?p ?o ?g. }

• W2950951682 abstract "Abstract Traumatic brain injury (TBI) has become a major health concern worldwide, and the poor outcome of TBI increases the need for therapeutic improvement. Secondary injuries following TBI, including excitotoxicity, lead to synaptic dysfunction and provide potential targets for intervention. Postsynaptic scaffold proteins, which are involved in the regulation of excitotoxicity after neuronal injury, play a crucial role in modulating synaptic function. Therefore, exploring the role of postsynaptic scaffold proteins in TBI might uncover new treatments. In this study, we demonstrated that downregulated expression of the postsynaptic scaffold protein Preso protects against neuronal injury after TBI in vitro and in vivo, and these effects are related to the inhibition of N-methyl-D-aspartate receptor (NMDAR) function. Further study showed that Preso facilitates signaling from NMDAR to nitric oxide (NO) and calcium (Ca 2+ ) responses. First, the complex constituting NMDAR, postsynaptic density-95 (PSD-95), and neuronal nitric oxide synthase (nNOS) was shown to be involved in the Preso regulation of the NO response. Uncoupling the linkage between Preso and PSD-95 attenuated the stability of this complex and suppressed the regulatory effect of Preso on the NO response. In addition, phosphorylation of NMDAR by cyclin-dependent kinase 5 (CDK5) was shown to be responsible for the Preso-mediated Ca 2+ response, which was dependent on the interaction between Preso and CDK5. These results suggested that the association of Preso with NMDAR signaling can serve as a target for neuroprotection against TBI." @default.
• W2950951682 created "2019-06-27" @default.
• W2950951682 creator A5005714529 @default.
• W2950951682 creator A5029708895 @default.
• W2950951682 creator A5033231648 @default.
• W2950951682 creator A5035226758 @default.
• W2950951682 creator A5050398965 @default.
• W2950951682 creator A5062078391 @default.
• W2950951682 creator A5062678004 @default.
• W2950951682 creator A5063641627 @default.
• W2950951682 creator A5064813504 @default.
• W2950951682 creator A5083340325 @default.
• W2950951682 creator A5083620120 @default.
• W2950951682 creator A5089800760 @default.
• W2950951682 date "2019-06-24" @default.
• W2950951682 modified "2023-10-14" @default.
• W2950951682 title "Preso regulates NMDA receptor-mediated excitotoxicity via modulating nitric oxide and calcium responses after traumatic brain injury" @default.
• W2950951682 cites W1521201094 @default.
• W2950951682 cites W1969417329 @default.
• W2950951682 cites W1970851711 @default.
• W2950951682 cites W1975564029 @default.
• W2950951682 cites W1990603467 @default.
• W2950951682 cites W1996198347 @default.
• W2950951682 cites W2002590408 @default.
• W2950951682 cites W2005354224 @default.
• W2950951682 cites W2008030217 @default.
• W2950951682 cites W2014786802 @default.
• W2950951682 cites W2034269718 @default.
• W2950951682 cites W2040704538 @default.
• W2950951682 cites W2049687017 @default.
• W2950951682 cites W2064086445 @default.
• W2950951682 cites W2065828939 @default.
• W2950951682 cites W2073814752 @default.
• W2950951682 cites W2084108178 @default.
• W2950951682 cites W2090521738 @default.
• W2950951682 cites W2092146149 @default.
• W2950951682 cites W2097497116 @default.
• W2950951682 cites W2147203461 @default.
• W2950951682 cites W2156653705 @default.
• W2950951682 cites W2335800452 @default.
• W2950951682 cites W2399673856 @default.
• W2950951682 cites W2552292530 @default.
• W2950951682 cites W2587047334 @default.
• W2950951682 cites W2599265248 @default.
• W2950951682 cites W2748602888 @default.
• W2950951682 cites W2767813783 @default.
• W2950951682 cites W574517765 @default.
• W2950951682 cites W879716227 @default.
• W2950951682 doi "https://doi.org/10.1038/s41419-019-1731-x" @default.
• W2950951682 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6591282" @default.
• W2950951682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31235685" @default.
• W2950951682 hasPublicationYear "2019" @default.
• W2950951682 type Work @default.
• W2950951682 sameAs 2950951682 @default.
• W2950951682 citedByCount "22" @default.
• W2950951682 countsByYear W29509516822019 @default.
• W2950951682 countsByYear W29509516822020 @default.
• W2950951682 countsByYear W29509516822021 @default.
• W2950951682 countsByYear W29509516822022 @default.
• W2950951682 countsByYear W29509516822023 @default.
• W2950951682 crossrefType "journal-article" @default.
• W2950951682 hasAuthorship W2950951682A5005714529 @default.
• W2950951682 hasAuthorship W2950951682A5029708895 @default.
• W2950951682 hasAuthorship W2950951682A5033231648 @default.
• W2950951682 hasAuthorship W2950951682A5035226758 @default.
• W2950951682 hasAuthorship W2950951682A5050398965 @default.
• W2950951682 hasAuthorship W2950951682A5062078391 @default.
• W2950951682 hasAuthorship W2950951682A5062678004 @default.
• W2950951682 hasAuthorship W2950951682A5063641627 @default.
• W2950951682 hasAuthorship W2950951682A5064813504 @default.
• W2950951682 hasAuthorship W2950951682A5083340325 @default.
• W2950951682 hasAuthorship W2950951682A5083620120 @default.
• W2950951682 hasAuthorship W2950951682A5089800760 @default.
• W2950951682 hasBestOaLocation W29509516821 @default.
• W2950951682 hasConcept C118552586 @default.
• W2950951682 hasConcept C169760540 @default.
• W2950951682 hasConcept C170493617 @default.
• W2950951682 hasConcept C185592680 @default.
• W2950951682 hasConcept C187541742 @default.
• W2950951682 hasConcept C197341189 @default.
• W2950951682 hasConcept C25498285 @default.
• W2950951682 hasConcept C2781012912 @default.
• W2950951682 hasConcept C2781017439 @default.
• W2950951682 hasConcept C55493867 @default.
• W2950951682 hasConcept C61174792 @default.
• W2950951682 hasConcept C67018056 @default.
• W2950951682 hasConcept C71924100 @default.
• W2950951682 hasConcept C86803240 @default.
• W2950951682 hasConcept C95444343 @default.
• W2950951682 hasConcept C98274493 @default.
• W2950951682 hasConceptScore W2950951682C118552586 @default.
• W2950951682 hasConceptScore W2950951682C169760540 @default.
• W2950951682 hasConceptScore W2950951682C170493617 @default.
• W2950951682 hasConceptScore W2950951682C185592680 @default.
• W2950951682 hasConceptScore W2950951682C187541742 @default.
• W2950951682 hasConceptScore W2950951682C197341189 @default.
• W2950951682 hasConceptScore W2950951682C25498285 @default.
• W2950951682 hasConceptScore W2950951682C2781012912 @default.
• W2950951682 hasConceptScore W2950951682C2781017439 @default.
• W2950951682 hasConceptScore W2950951682C55493867 @default.

• next