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• W2950961795 abstract "Abstract The isotype-specific composition of the keratin cytoskeleton is important for strong adhesion, force resilience, and barrier function of the epidermis. However, the mechanisms by which keratins regulate these functions are still incompletely understood. In this study, the role and significance of the keratin network for mechanical integrity, force transmission, and barrier formation were analyzed in murine keratinocytes. Following the time-course of single-cell wounding, wildtype (WT) cells slowly closed the gap in a collective fashion involving tightly connected neighboring cells. In contrast, the mechanical response of neighboring cells was compromised in keratin-deficient cells, causing an increased wound area initially and an inefficient overall wound closure. Furthermore, the loss of the keratin network led to impaired, fragmented cell-cell junctions and triggered a profound change in the overall cellular actomyosin architecture. Electrical cell-substrate impedance sensing of cell junctions revealed a dysfunctional barrier in knockout (Kty −/− ) compared to WT cells. These findings demonstrate that Kty −/− cells display a novel phenotype characterized by loss of mechanocoupling and failure to form a functional barrier. Re-expression of K5/K14 rescued the barrier defect to a significant extent and reestablished the mechanocoupling with remaining discrepancies likely due to the low abundance of keratins in that setting. Our study reveals the major role of the keratin network for mechanical homeostasis and barrier functionality in keratinocyte layers." @default.
• W2950961795 created "2019-06-27" @default.
• W2950961795 creator A5005609261 @default.
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• W2950961795 date "2019-06-11" @default.
• W2950961795 modified "2023-09-23" @default.
• W2950961795 title "An intact keratin network is crucial for mechanical integrity and barrier function in keratinocyte cell sheets" @default.
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• W2950961795 doi "https://doi.org/10.1101/661462" @default.
• W2950961795 hasPublicationYear "2019" @default.
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