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- W2950963604 abstract "Adgrg6 (Gpr126) is an adhesion class G protein-coupled receptor with a conserved role in myelination of the peripheral nervous system. In the zebrafish, mutation of adgrg6 also results in defects in the inner ear: otic tissue fails to down-regulate versican gene expression and morphogenesis is disrupted. We have designed a whole-animal screen that tests for rescue of both up- and down-regulated gene expression in mutant embryos, together with analysis of weak and strong alleles. From a screen of 3120 structurally diverse compounds, we have identified 68 that reduce versican b expression in the adgrg6 mutant ear, 41 of which also restore myelin basic protein gene expression in Schwann cells of mutant embryos. Nineteen compounds unable to rescue a strong adgrg6 allele provide candidates for molecules that may interact directly with the Adgrg6 receptor. Our pipeline provides a powerful approach for identifying compounds that modulate GPCR activity, with potential impact for future drug design." @default.
- W2950963604 created "2019-06-27" @default.
- W2950963604 creator A5000589129 @default.
- W2950963604 creator A5023019422 @default.
- W2950963604 creator A5030046388 @default.
- W2950963604 creator A5038150834 @default.
- W2950963604 creator A5052237631 @default.
- W2950963604 creator A5058998142 @default.
- W2950963604 creator A5063475106 @default.
- W2950963604 creator A5064880962 @default.
- W2950963604 creator A5072720132 @default.
- W2950963604 date "2019-06-10" @default.
- W2950963604 modified "2023-10-18" @default.
- W2950963604 title "Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant" @default.
- W2950963604 cites W1146096253 @default.
- W2950963604 cites W1169326313 @default.
- W2950963604 cites W1508604947 @default.
- W2950963604 cites W1809211386 @default.
- W2950963604 cites W1919727069 @default.
- W2950963604 cites W1975147762 @default.
- W2950963604 cites W1975560014 @default.
- W2950963604 cites W1976391205 @default.
- W2950963604 cites W1978121032 @default.
- W2950963604 cites W1979900513 @default.
- W2950963604 cites W1980022376 @default.
- W2950963604 cites W1981495821 @default.
- W2950963604 cites W1983080072 @default.
- W2950963604 cites W1988037271 @default.
- W2950963604 cites W1992599562 @default.
- W2950963604 cites W1996087867 @default.
- W2950963604 cites W1998198360 @default.
- W2950963604 cites W1999420091 @default.
- W2950963604 cites W2000508433 @default.
- W2950963604 cites W2000839039 @default.
- W2950963604 cites W2011301426 @default.
- W2950963604 cites W2011353038 @default.
- W2950963604 cites W2021218920 @default.
- W2950963604 cites W2022515140 @default.
- W2950963604 cites W2026515229 @default.
- W2950963604 cites W2027844138 @default.
- W2950963604 cites W2034476680 @default.
- W2950963604 cites W2039055179 @default.
- W2950963604 cites W2040120130 @default.
- W2950963604 cites W2040675127 @default.
- W2950963604 cites W2041019578 @default.
- W2950963604 cites W2047642636 @default.
- W2950963604 cites W2050376918 @default.
- W2950963604 cites W2053188090 @default.
- W2950963604 cites W2060531713 @default.
- W2950963604 cites W2063063761 @default.
- W2950963604 cites W2066023589 @default.
- W2950963604 cites W2072316722 @default.
- W2950963604 cites W2077537177 @default.
- W2950963604 cites W2096729078 @default.
- W2950963604 cites W2099694670 @default.
- W2950963604 cites W2103136993 @default.
- W2950963604 cites W2103947324 @default.
- W2950963604 cites W2104968232 @default.
- W2950963604 cites W2106303663 @default.
- W2950963604 cites W2107841008 @default.
- W2950963604 cites W2114536971 @default.
- W2950963604 cites W2123936150 @default.
- W2950963604 cites W2134268326 @default.
- W2950963604 cites W2142083102 @default.
- W2950963604 cites W2153649171 @default.
- W2950963604 cites W2155048725 @default.
- W2950963604 cites W2157042469 @default.
- W2950963604 cites W2159319913 @default.
- W2950963604 cites W2159675211 @default.
- W2950963604 cites W2163176575 @default.
- W2950963604 cites W2166790467 @default.
- W2950963604 cites W2211218327 @default.
- W2950963604 cites W2212055661 @default.
- W2950963604 cites W2269303230 @default.
- W2950963604 cites W2293199886 @default.
- W2950963604 cites W2301530891 @default.
- W2950963604 cites W2302115886 @default.
- W2950963604 cites W2336828812 @default.
- W2950963604 cites W2343581590 @default.
- W2950963604 cites W2344942352 @default.
- W2950963604 cites W2397751594 @default.
- W2950963604 cites W2413335515 @default.
- W2950963604 cites W2415553457 @default.
- W2950963604 cites W2484285038 @default.
- W2950963604 cites W2498296569 @default.
- W2950963604 cites W2517036415 @default.
- W2950963604 cites W2522147339 @default.
- W2950963604 cites W2539886351 @default.
- W2950963604 cites W2547136347 @default.
- W2950963604 cites W2565129115 @default.
- W2950963604 cites W2565849713 @default.
- W2950963604 cites W2568121822 @default.
- W2950963604 cites W2580733882 @default.
- W2950963604 cites W2604480729 @default.
- W2950963604 cites W2604716987 @default.
- W2950963604 cites W2749455529 @default.
- W2950963604 cites W2751716123 @default.
- W2950963604 cites W2753524273 @default.
- W2950963604 cites W2765153686 @default.
- W2950963604 cites W2770574423 @default.