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- W2950973364 abstract "The chemistry and pharmacology of the title compound, spirolactone 4, are reported. The synthesis represents a new approach to the preparation of spiro compounds. The pharmacological profiles of 4 are compared to that of clofibrate in Triton-induced hyperlipidemic, sucrose-fed, and normal Sprague-Dawley rat models. Clofibrate was effective in all animal models, but the spirolactone 4 exhibited antitriglyceridemic activity only in the Triton model. The inactivity of 4 in sucrose- and chow-fed rats could not be attributed to a resistance to hydrolysis by serum esterases. Comparative studies revealed that inhibition of hepatic HMG-CoA reductase activity may not be an index of hypocholesterolemic action in sucrose-fed rats. Additionally, only clofibrate exhibited significant changes in components of the hepatic microsomal monooxygenase system." @default.
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- W2950973364 date "1979-05-01" @default.
- W2950973364 modified "2023-09-27" @default.
- W2950973364 title "ChemInform Abstract: SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF A CLOFIBRATE-RELATED TRICYCLIC SPIROLACTONE, 5-CHLORO-4′,5′-DIHYDROSPIRO(BENZOFURAN-2(3H),3′(2′H)-FURAN)-2′-ONE" @default.
- W2950973364 cites W1979980697 @default.
- W2950973364 doi "https://doi.org/10.1002/chin.197918233" @default.
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