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- W2950974743 abstract "Abstract Giant viruses are ecologically important players in aquatic ecosystems that have challenged concepts of what constitutes a virus. Herein, we present the giant Bodo saltans virus (BsV), the first characterized representative of the most abundant giant viruses in the oceans, and the first klosneuvirus isolate, a subgroup of the Mimiviridae proposed from metagenomic data. BsV infects an ecologically important microzooplankton, the kinetoplastid Bodo saltans . Its 1.39 Mb genome is the largest described for the Mimiviridae and encodes 1227 predicted ORFs, including pathways for host-independent replication. Yet, much of its translational machinery has been lost, including all tRNAs. Essential genes are invaded by homing endonuclease-encoding self-splicing introns that may defend against competing viruses. Putative anti-host factors show extensive gene duplication via a genomic accordion indicating an ongoing evolutionary arms race and highlighting the rapid evolution and genomic plasticity that has led to genome gigantism and the enigma that is giant viruses." @default.
- W2950974743 created "2019-06-27" @default.
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- W2950974743 date "2017-11-06" @default.
- W2950974743 modified "2023-09-26" @default.
- W2950974743 title "The kinetoplastid-infecting Bodo saltans virus (BsV), a window into the most abundant giant viruses in the sea" @default.
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- W2950974743 doi "https://doi.org/10.1101/214536" @default.
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