Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950993348> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2950993348 abstract "Folding of Ubiquitin (Ub) is investigated at low and neutral pH at different temperatures using simulations of the coarse-grained Self-Organized-Polymer model with side chains. The calculated radius of gyration, showing dramatic variations with pH, is in excellent agreement with scattering experiments. At $T_m$ Ub folds in a two-state manner at low and neutral pH. Clustering analysis of the conformations sampled in equilibrium folding trajectories at $T_m$, with multiple transitions between the folded and unfolded states, show a network of metastable states connecting the native and unfolded states. At low and neutral pH, Ub folds with high probability through a preferred set of conformations resulting in a pH-dependent dominant folding pathway. Folding kinetics reveal that Ub assembly at low pH occurs by multiple pathways involving a combination of nucleation-collapse and diffusion collision mechanism. The mechanism by which Ub folds is dictated by the stability of the key secondary structural elements responsible for establishing long range contacts and collapse of Ub. Nucleation collapse mechanism holds if the stability of these elements are marginal, as would be the case at elevated temperatures. If the lifetimes associated with these structured microdomains are on the order of hundreds of $mu sec$ then Ub folding follows the diffusion-collision mechanism with intermediates many of which coincide with those found in equilibrium. Folding at neutral pH is a sequential process with a populated intermediate resembling that sampled at equilibrium. The transition state structures, obtained using a $P_{fold}$ analysis, are homogeneous and globular with most of the secondary and tertiary structures being native-like. Many of our findings are not only in agreement with experiments but also provide missing details not resolvable in standard experiments." @default.
- W2950993348 created "2019-06-27" @default.
- W2950993348 creator A5036725653 @default.
- W2950993348 creator A5075084768 @default.
- W2950993348 date "2015-07-07" @default.
- W2950993348 modified "2023-10-16" @default.
- W2950993348 title "Dissecting Ubiquitin Folding Using the Self-Organized Polymer Model" @default.
- W2950993348 cites W1968827368 @default.
- W2950993348 cites W1989925383 @default.
- W2950993348 cites W2080131977 @default.
- W2950993348 cites W2083174976 @default.
- W2950993348 cites W2122680286 @default.
- W2950993348 doi "https://doi.org/10.48550/arxiv.1507.02007" @default.
- W2950993348 hasPublicationYear "2015" @default.
- W2950993348 type Work @default.
- W2950993348 sameAs 2950993348 @default.
- W2950993348 citedByCount "0" @default.
- W2950993348 crossrefType "posted-content" @default.
- W2950993348 hasAuthorship W2950993348A5036725653 @default.
- W2950993348 hasAuthorship W2950993348A5075084768 @default.
- W2950993348 hasBestOaLocation W29509933481 @default.
- W2950993348 hasConcept C105168689 @default.
- W2950993348 hasConcept C119599485 @default.
- W2950993348 hasConcept C121332964 @default.
- W2950993348 hasConcept C127413603 @default.
- W2950993348 hasConcept C148898269 @default.
- W2950993348 hasConcept C159467904 @default.
- W2950993348 hasConcept C162203774 @default.
- W2950993348 hasConcept C168568712 @default.
- W2950993348 hasConcept C174507519 @default.
- W2950993348 hasConcept C178790620 @default.
- W2950993348 hasConcept C185592680 @default.
- W2950993348 hasConcept C19472624 @default.
- W2950993348 hasConcept C204328495 @default.
- W2950993348 hasConcept C206276672 @default.
- W2950993348 hasConcept C2776545253 @default.
- W2950993348 hasConcept C46449900 @default.
- W2950993348 hasConcept C521977710 @default.
- W2950993348 hasConcept C55493867 @default.
- W2950993348 hasConcept C61048295 @default.
- W2950993348 hasConcept C62520636 @default.
- W2950993348 hasConcept C8010536 @default.
- W2950993348 hasConcept C89464430 @default.
- W2950993348 hasConcept C97355855 @default.
- W2950993348 hasConceptScore W2950993348C105168689 @default.
- W2950993348 hasConceptScore W2950993348C119599485 @default.
- W2950993348 hasConceptScore W2950993348C121332964 @default.
- W2950993348 hasConceptScore W2950993348C127413603 @default.
- W2950993348 hasConceptScore W2950993348C148898269 @default.
- W2950993348 hasConceptScore W2950993348C159467904 @default.
- W2950993348 hasConceptScore W2950993348C162203774 @default.
- W2950993348 hasConceptScore W2950993348C168568712 @default.
- W2950993348 hasConceptScore W2950993348C174507519 @default.
- W2950993348 hasConceptScore W2950993348C178790620 @default.
- W2950993348 hasConceptScore W2950993348C185592680 @default.
- W2950993348 hasConceptScore W2950993348C19472624 @default.
- W2950993348 hasConceptScore W2950993348C204328495 @default.
- W2950993348 hasConceptScore W2950993348C206276672 @default.
- W2950993348 hasConceptScore W2950993348C2776545253 @default.
- W2950993348 hasConceptScore W2950993348C46449900 @default.
- W2950993348 hasConceptScore W2950993348C521977710 @default.
- W2950993348 hasConceptScore W2950993348C55493867 @default.
- W2950993348 hasConceptScore W2950993348C61048295 @default.
- W2950993348 hasConceptScore W2950993348C62520636 @default.
- W2950993348 hasConceptScore W2950993348C8010536 @default.
- W2950993348 hasConceptScore W2950993348C89464430 @default.
- W2950993348 hasConceptScore W2950993348C97355855 @default.
- W2950993348 hasLocation W29509933481 @default.
- W2950993348 hasLocation W29509933482 @default.
- W2950993348 hasLocation W29509933483 @default.
- W2950993348 hasOpenAccess W2950993348 @default.
- W2950993348 hasPrimaryLocation W29509933481 @default.
- W2950993348 hasRelatedWork W1971832114 @default.
- W2950993348 hasRelatedWork W1991889785 @default.
- W2950993348 hasRelatedWork W2003225518 @default.
- W2950993348 hasRelatedWork W2013835544 @default.
- W2950993348 hasRelatedWork W2056176287 @default.
- W2950993348 hasRelatedWork W2095205630 @default.
- W2950993348 hasRelatedWork W2240530368 @default.
- W2950993348 hasRelatedWork W2950993348 @default.
- W2950993348 hasRelatedWork W3122332926 @default.
- W2950993348 hasRelatedWork W4232856400 @default.
- W2950993348 isParatext "false" @default.
- W2950993348 isRetracted "false" @default.
- W2950993348 magId "2950993348" @default.
- W2950993348 workType "article" @default.