FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950997691> ?p ?o ?g. }

• W2950997691 abstract "Background: Inflammatory bowel disease (IBD) related arthropathy may manifest as peripheral arthritis, dactylitis or enthesitis as well as inflammatory back pain (IBP) due to sacroiliac joint (SIJ) and/or spinal inflammation. HLA-B27 correlates with the presence of MRI determined SIJ bone marrow oedema (BMO) in axial spondyloarthritis (axSpA) and axial psoriatic arthritis (PsA) patients. The prevalence of HLA-B27 positivity is low in IBD and patients may already be on therapy that potentially modifies MRI spinal lesions at the time of imaging. Objectives: To evaluate the utility of MRI to aid the diagnosis of axSpA in IBD patients with IBP and to explore the relationship of MRI abnormalities with HLA-B27 status. Methods: Cross-sectional, retrospective audit of consecutive MRI scans of the SIJ and spine performed (2008-2018) in a large teaching hospital. All scans were requested in IBD patients presenting with IBP and clinical suspicion of axSpA. Demographic and clinical data were retrieved from the medical notes. Decision from the clinician whether the patient had axSpA related to the IBD was also recorded. MRI scans were scored by 2 readers using the semiquantitative Leeds Scoring System (BMO grade from 0 to 3)1. An overall score for inflammatory (sum of SIJ and Spine BMO scores) and structural lesions (sum of lesions per quadrant) was calculated. Results: MRI scans from 119 IBD (Crohn’s n=82, ulcerative colitis n=31, and undifferentiated IBD n=6) patients were available for analysis. 63.9% were female, mean age 38.7 years at time of MRI with mean age of IBP onset 36.3 years. The majority (n=65/83, 78.3%) were HLA-B27 negative (missing data n=36). Thirty subjects were receiving biologic therapy for IBD. A summary of MRI findings (SIJ and spine) is shown on Table 1. Degenerative disc disease was common in the cohort with 55/119 having at least one affected level. Other incidental findings included: hemangiomas (n=8), osteoporotic fractures (n=2) and myeloma (n=1). The total BMO MRI scores (Spine plus SIJ), SIJ only BMO score, erosions, sclerosis and fat scores were higher in the HLA-B27 positive group as seen in Figure 1, with only differences in the erosion (P=0.002) and sclerosis score (P=0.038) being statistically significant. Less active (BMO) and structural lesions were seen in the biologic treated group, reaching statistical significance in total BMO (P=0.041), erosions (P=0.039), fat (P=0.003) and sclerosis (P=0.013) scores. A clinical diagnosis of axial SpA was made in 42/119 (35%) cases. Of these, n=25/42 had BMO (SIJ or spine) and structural lesions. Structural lesions alone were evident in 13/42 of these cases. BMO lesions alone with no structural changes was found in 2 cases (grade 1). Conclusion: MRI findings of sacroiliitis and spinal involvement, defined as a combination of active and structural lesions, are common in IBD subjects with symptomatic back pain. The low prevalence of BMO seen in this cohort may represent partially treated disease. The addition of structural lesions to the current definitions of a positive MRI, may help with the diagnosis of axSpA. The presence of HLA-B27 positivity appears to define a more severe axial phenotype in IBD associated axSpA. References [1] Marzo-Ortega H, et al. Ann Rheum Dis2009; 68:1721–7. Disclosure of interests: Xabier Michelena-Vegas: None declared, Leticia Garcia-Montoya: None declared, Gabriele De Marco: None declared, Dennis McGonagle Consultant for: Lilly, Novartis UCB, Speakers bureau: Lilly, Novartis UCB, John Hamlin: None declared, Christian Selinger: None declared, Helena Marzo-Ortega Grant/research support from: Janssen, Novartis and Pfizer, Consultant for: abbVie, Celgene, Janssen, Eli-Lilly, Novartis and UCB, Speakers bureau: abbVie, Celgene, Janssen, Eli-Lilly, Novartis and UCB" @default.
• W2950997691 created "2019-06-27" @default.
• W2950997691 creator A5020807769 @default.
• W2950997691 creator A5053315948 @default.
• W2950997691 creator A5056679799 @default.
• W2950997691 creator A5069154249 @default.
• W2950997691 creator A5071307383 @default.
• W2950997691 creator A5074519726 @default.
• W2950997691 creator A5076631930 @default.
• W2950997691 date "2019-06-01" @default.
• W2950997691 modified "2023-10-06" @default.
• W2950997691 title "AB0727 MAGNETIC RESONANCE IMAGING IN SYMPTOMATIC BACK PAIN IN INFLAMMATORY BOWEL DISEASE: STRUCTURAL LESIONS AND HLA-B27 IMPROVE THE DIAGNOSTIC ACCURACY IN AXIAL SPONDYLOARTHRITIS" @default.
• W2950997691 doi "https://doi.org/10.1136/annrheumdis-2019-eular.6921" @default.
• W2950997691 hasPublicationYear "2019" @default.
• W2950997691 type Work @default.
• W2950997691 sameAs 2950997691 @default.
• W2950997691 citedByCount "0" @default.
• W2950997691 crossrefType "proceedings-article" @default.
• W2950997691 hasAuthorship W2950997691A5020807769 @default.
• W2950997691 hasAuthorship W2950997691A5053315948 @default.
• W2950997691 hasAuthorship W2950997691A5056679799 @default.
• W2950997691 hasAuthorship W2950997691A5069154249 @default.
• W2950997691 hasAuthorship W2950997691A5071307383 @default.
• W2950997691 hasAuthorship W2950997691A5074519726 @default.
• W2950997691 hasAuthorship W2950997691A5076631930 @default.
• W2950997691 hasBestOaLocation W29509976911 @default.
• W2950997691 hasConcept C126322002 @default.
• W2950997691 hasConcept C126838900 @default.
• W2950997691 hasConcept C142724271 @default.
• W2950997691 hasConcept C143409427 @default.
• W2950997691 hasConcept C147483822 @default.
• W2950997691 hasConcept C188280979 @default.
• W2950997691 hasConcept C203014093 @default.
• W2950997691 hasConcept C204787440 @default.
• W2950997691 hasConcept C2776260265 @default.
• W2950997691 hasConcept C2776501849 @default.
• W2950997691 hasConcept C2777077863 @default.
• W2950997691 hasConcept C2777365958 @default.
• W2950997691 hasConcept C2777402515 @default.
• W2950997691 hasConcept C2778019847 @default.
• W2950997691 hasConcept C2778091532 @default.
• W2950997691 hasConcept C2778260677 @default.
• W2950997691 hasConcept C2778579456 @default.
• W2950997691 hasConcept C2778614933 @default.
• W2950997691 hasConcept C2779134260 @default.
• W2950997691 hasConcept C2780131103 @default.
• W2950997691 hasConcept C2780479503 @default.
• W2950997691 hasConcept C2780639617 @default.
• W2950997691 hasConcept C71924100 @default.
• W2950997691 hasConceptScore W2950997691C126322002 @default.
• W2950997691 hasConceptScore W2950997691C126838900 @default.
• W2950997691 hasConceptScore W2950997691C142724271 @default.
• W2950997691 hasConceptScore W2950997691C143409427 @default.
• W2950997691 hasConceptScore W2950997691C147483822 @default.
• W2950997691 hasConceptScore W2950997691C188280979 @default.
• W2950997691 hasConceptScore W2950997691C203014093 @default.
• W2950997691 hasConceptScore W2950997691C204787440 @default.
• W2950997691 hasConceptScore W2950997691C2776260265 @default.
• W2950997691 hasConceptScore W2950997691C2776501849 @default.
• W2950997691 hasConceptScore W2950997691C2777077863 @default.
• W2950997691 hasConceptScore W2950997691C2777365958 @default.
• W2950997691 hasConceptScore W2950997691C2777402515 @default.
• W2950997691 hasConceptScore W2950997691C2778019847 @default.
• W2950997691 hasConceptScore W2950997691C2778091532 @default.
• W2950997691 hasConceptScore W2950997691C2778260677 @default.
• W2950997691 hasConceptScore W2950997691C2778579456 @default.
• W2950997691 hasConceptScore W2950997691C2778614933 @default.
• W2950997691 hasConceptScore W2950997691C2779134260 @default.
• W2950997691 hasConceptScore W2950997691C2780131103 @default.
• W2950997691 hasConceptScore W2950997691C2780479503 @default.
• W2950997691 hasConceptScore W2950997691C2780639617 @default.
• W2950997691 hasConceptScore W2950997691C71924100 @default.
• W2950997691 hasLocation W29509976911 @default.
• W2950997691 hasOpenAccess W2950997691 @default.
• W2950997691 hasPrimaryLocation W29509976911 @default.
• W2950997691 hasRelatedWork W1967057447 @default.
• W2950997691 hasRelatedWork W1990173325 @default.
• W2950997691 hasRelatedWork W2091868681 @default.
• W2950997691 hasRelatedWork W2317259210 @default.
• W2950997691 hasRelatedWork W2317711844 @default.
• W2950997691 hasRelatedWork W2321509352 @default.
• W2950997691 hasRelatedWork W2326058990 @default.
• W2950997691 hasRelatedWork W2329662880 @default.
• W2950997691 hasRelatedWork W2335595658 @default.
• W2950997691 hasRelatedWork W2395250360 @default.
• W2950997691 hasRelatedWork W2415521428 @default.
• W2950997691 hasRelatedWork W2552659247 @default.
• W2950997691 hasRelatedWork W2553062223 @default.
• W2950997691 hasRelatedWork W2900516498 @default.
• W2950997691 hasRelatedWork W2910482765 @default.
• W2950997691 hasRelatedWork W2951346891 @default.
• W2950997691 hasRelatedWork W2988027685 @default.
• W2950997691 hasRelatedWork W3010814826 @default.
• W2950997691 hasRelatedWork W3172128081 @default.
• W2950997691 hasRelatedWork W2401634557 @default.
• W2950997691 isParatext "false" @default.
• W2950997691 isRetracted "false" @default.
• W2950997691 magId "2950997691" @default.
• W2950997691 workType "article" @default.