FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951031181> ?p ?o ?g. }

• W2951031181 endingPage "424" @default.
• W2951031181 startingPage "410" @default.
• W2951031181 abstract "Much work has been devoted to analysing thermodynamic models for solid dispersions with a view to identifying regions in the phase diagram where amorphous phase separation or drug recrystallization can occur. However, detailed partial differential equation non-equilibrium models that track the evolution of solid dispersions in time and space are lacking. Hence theoretical predictions for the timescale over which phase separation occurs in a solid dispersion are not available. In this paper, we address some of these deficiencies by (i) constructing a general multicomponent diffusion model for a dissolving solid dispersion; (ii) specializing the model to a binary drug/polymer system in storage; (iii) deriving an effective concentration dependent drug diffusion coefficient for the binary system, thereby obtaining a theoretical prediction for the timescale over which phase separation occurs; and (iv) presenting a detailed numerical investigation of the HPMCAS/Felodipine system assuming a Flory-Huggins activity coefficient. The numerical simulations exhibit numerous interesting phenomena, such as the formation of polymer droplets and strings, Ostwald ripening/coarsening, phase inversion, and droplet-to-string transitions." @default.
• W2951031181 created "2019-06-27" @default.
• W2951031181 creator A5046203971 @default.
• W2951031181 creator A5049151547 @default.
• W2951031181 creator A5053158394 @default.
• W2951031181 date "2019-08-01" @default.
• W2951031181 modified "2023-10-16" @default.
• W2951031181 title "Modelling phase separation in amorphous solid dispersions" @default.
• W2951031181 cites W1195955210 @default.
• W2951031181 cites W1663468437 @default.
• W2951031181 cites W1709522924 @default.
• W2951031181 cites W1799995363 @default.
• W2951031181 cites W1934180859 @default.
• W2951031181 cites W1968508314 @default.
• W2951031181 cites W1986251008 @default.
• W2951031181 cites W1990521308 @default.
• W2951031181 cites W2001533174 @default.
• W2951031181 cites W2015203678 @default.
• W2951031181 cites W2020703654 @default.
• W2951031181 cites W2041278780 @default.
• W2951031181 cites W2044146593 @default.
• W2951031181 cites W2046528357 @default.
• W2951031181 cites W2063507624 @default.
• W2951031181 cites W2069804811 @default.
• W2951031181 cites W2071419277 @default.
• W2951031181 cites W2076393316 @default.
• W2951031181 cites W2081616039 @default.
• W2951031181 cites W2085385924 @default.
• W2951031181 cites W2133061394 @default.
• W2951031181 cites W2166295771 @default.
• W2951031181 cites W2190949340 @default.
• W2951031181 cites W2429356704 @default.
• W2951031181 cites W2570578587 @default.
• W2951031181 cites W2578803489 @default.
• W2951031181 cites W2763485858 @default.
• W2951031181 cites W2765971788 @default.
• W2951031181 cites W2773147461 @default.
• W2951031181 cites W2900881918 @default.
• W2951031181 doi "https://doi.org/10.1016/j.actbio.2019.06.009" @default.
• W2951031181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31238110" @default.
• W2951031181 hasPublicationYear "2019" @default.
• W2951031181 type Work @default.
• W2951031181 sameAs 2951031181 @default.
• W2951031181 citedByCount "15" @default.
• W2951031181 countsByYear W29510311812019 @default.
• W2951031181 countsByYear W29510311812020 @default.
• W2951031181 countsByYear W29510311812021 @default.
• W2951031181 countsByYear W29510311812022 @default.
• W2951031181 countsByYear W29510311812023 @default.
• W2951031181 crossrefType "journal-article" @default.
• W2951031181 hasAuthorship W2951031181A5046203971 @default.
• W2951031181 hasAuthorship W2951031181A5049151547 @default.
• W2951031181 hasAuthorship W2951031181A5053158394 @default.
• W2951031181 hasBestOaLocation W29510311812 @default.
• W2951031181 hasConcept C120665830 @default.
• W2951031181 hasConcept C121332964 @default.
• W2951031181 hasConcept C121864883 @default.
• W2951031181 hasConcept C138999460 @default.
• W2951031181 hasConcept C147789679 @default.
• W2951031181 hasConcept C151730666 @default.
• W2951031181 hasConcept C159467904 @default.
• W2951031181 hasConcept C171250308 @default.
• W2951031181 hasConcept C177562468 @default.
• W2951031181 hasConcept C185592680 @default.
• W2951031181 hasConcept C18762648 @default.
• W2951031181 hasConcept C191897082 @default.
• W2951031181 hasConcept C192562407 @default.
• W2951031181 hasConcept C195702682 @default.
• W2951031181 hasConcept C44280652 @default.
• W2951031181 hasConcept C56052488 @default.
• W2951031181 hasConcept C62129180 @default.
• W2951031181 hasConcept C62520636 @default.
• W2951031181 hasConcept C8010536 @default.
• W2951031181 hasConcept C85906118 @default.
• W2951031181 hasConcept C86803240 @default.
• W2951031181 hasConcept C88380143 @default.
• W2951031181 hasConcept C97355855 @default.
• W2951031181 hasConceptScore W2951031181C120665830 @default.
• W2951031181 hasConceptScore W2951031181C121332964 @default.
• W2951031181 hasConceptScore W2951031181C121864883 @default.
• W2951031181 hasConceptScore W2951031181C138999460 @default.
• W2951031181 hasConceptScore W2951031181C147789679 @default.
• W2951031181 hasConceptScore W2951031181C151730666 @default.
• W2951031181 hasConceptScore W2951031181C159467904 @default.
• W2951031181 hasConceptScore W2951031181C171250308 @default.
• W2951031181 hasConceptScore W2951031181C177562468 @default.
• W2951031181 hasConceptScore W2951031181C185592680 @default.
• W2951031181 hasConceptScore W2951031181C18762648 @default.
• W2951031181 hasConceptScore W2951031181C191897082 @default.
• W2951031181 hasConceptScore W2951031181C192562407 @default.
• W2951031181 hasConceptScore W2951031181C195702682 @default.
• W2951031181 hasConceptScore W2951031181C44280652 @default.
• W2951031181 hasConceptScore W2951031181C56052488 @default.
• W2951031181 hasConceptScore W2951031181C62129180 @default.
• W2951031181 hasConceptScore W2951031181C62520636 @default.
• W2951031181 hasConceptScore W2951031181C8010536 @default.
• W2951031181 hasConceptScore W2951031181C85906118 @default.
• W2951031181 hasConceptScore W2951031181C86803240 @default.

• next