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• W2951031454 abstract "A large number of myocytes are necessary to treat intractable muscular disorders such as Duchenne muscular dystrophy with cell-based therapies. However, starting materials for cellular therapy products such as myoblasts, marrow stromal cells, menstrual blood-derived cells, and placenta-derived cells have a limited lifespan and cease to proliferate in vitro. From the viewpoints of manufacturing and quality control, cells with a long lifespan are more suitable as a starting material. In this study, we generated stromal cells for future myoblast therapy from a working cell bank of human embryonic stem cells (ESCs). The ESC-derived CD105+ cells with extensive in vitro proliferation capability exhibited myogenesis and genetic stability in vitro. These results imply that ESC-derived CD105+ cells are another cell source for myoblasts in cell-based therapy for patients with genetic muscular disorders. Since ESCs are immortal, mesenchymal stromal cells generated from ESCs can be manufactured at a large scale in one lot for pharmaceutical purposes." @default.
• W2951031454 created "2019-06-27" @default.
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• W2951031454 date "2017-01-01" @default.
• W2951031454 modified "2023-10-11" @default.
• W2951031454 title "Can Human Embryonic Stem Cell-Derived Stromal Cells Serve a Starting Material for Myoblasts?" @default.
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• W2951031454 doi "https://doi.org/10.1155/2017/7541734" @default.
• W2951031454 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5494578" @default.
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