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- W2951036000 abstract "Abstract Homocamptothecins are proving to be an especially interesting class of anti-cancer agents because they resemble standard camptothecins in cytotoxicity but have very different pharmacodyanamic properties. This review summarizes synthetic approaches to the parent homocamptothecin and its analogs. Three powerful and general routes—the Lavergne–Comins route, the cascade radical annulation route, and the Friedlander route—have been put into place to make homocamptothecins. These routes are compared and contrasted. Together, they have driven the SAR, preclinical, and clinical development of this class of anti-cancer agents." @default.
- W2951036000 created "2019-06-27" @default.
- W2951036000 creator A5058483916 @default.
- W2951036000 date "2009-09-29" @default.
- W2951036000 modified "2023-09-26" @default.
- W2951036000 title "ChemInform Abstract: Synthetic Approaches to Homocamptothecin Antitumor Agents" @default.
- W2951036000 cites W2060024234 @default.
- W2951036000 doi "https://doi.org/10.1002/chin.200939245" @default.
- W2951036000 hasPublicationYear "2009" @default.
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