FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951048045> ?p ?o ?g. }

• W2951048045 endingPage "104493" @default.
• W2951048045 startingPage "104493" @default.
• W2951048045 abstract "Glutamatergic excitotoxicity is crucial in the pathogenesis of epileptic seizures. Dexmedetomidine, a potent and highly selective α2 adrenoceptor agonist, inhibits glutamate release from nerve terminals in rat cerebrocortical nerve terminals. However, the ability of dexmedetomidine to affect glutamate-induced brain injury is still unknown. Therefore, the present study evaluated the protective effect of dexmedetomidine against brain damage by using a kainic acid (KA) rat model, a frequently used model for temporal lobe epilepsy. Rats were treated with dexmedetomidine (1 or 5 μg/kg, intraperitoneally) 30 min before the KA (15 mg/kg) intraperitoneal injection. KA-induced seizure score and elevations of glutamate release in rat hippocampi were inhibited by pretreatment with dexmedetomidine. Histopathological and TUNEL staining analyzes showed that dexmedetomidine attenuated KA-induced neuronal death in the hippocampus. Dexmedetomidine ameliorated KA-induced apoptosis, and this neuroprotective effect was accompanied by inhibited the KA-induced caspase-3 expression as well as MAPKs phosphorylation, and reversed Bcl-2 down-expression, coupled with increased Nrf2, BDNF and TrkB expression in KA-treated rats. The results suggest that dexmedetomidine protected rat brains from KA-induced excitotoxic damage by reducing glutamate levels, suppressing caspase-3 activation and MAPKs phosphorylation, and enhancing Bcl-2, Nrf2, BDNF and TrkB expression in the hippocampus. Therefore, dexmedetomidine may be beneficial for preventing or treating brain disorders associated with excitotoxic neuronal damage. In conclusion, these data suggest that dexmedetomidine has the therapeutic potential for treating epilepsy." @default.
• W2951048045 created "2019-06-27" @default.
• W2951048045 creator A5008950662 @default.
• W2951048045 creator A5025148084 @default.
• W2951048045 creator A5039433631 @default.
• W2951048045 creator A5053129505 @default.
• W2951048045 creator A5074471869 @default.
• W2951048045 creator A5082629853 @default.
• W2951048045 date "2019-10-01" @default.
• W2951048045 modified "2023-09-30" @default.
• W2951048045 title "Dexmedetomidine protects neurons from kainic acid-induced excitotoxicity by activating BDNF signaling" @default.
• W2951048045 cites W1603732963 @default.
• W2951048045 cites W1895508641 @default.
• W2951048045 cites W1969408505 @default.
• W2951048045 cites W1970127950 @default.
• W2951048045 cites W1972734453 @default.
• W2951048045 cites W1976172889 @default.
• W2951048045 cites W1978666210 @default.
• W2951048045 cites W1982255324 @default.
• W2951048045 cites W1987701698 @default.
• W2951048045 cites W1991583506 @default.
• W2951048045 cites W1996893328 @default.
• W2951048045 cites W1998930468 @default.
• W2951048045 cites W1999485470 @default.
• W2951048045 cites W2009582310 @default.
• W2951048045 cites W2018139629 @default.
• W2951048045 cites W2030056523 @default.
• W2951048045 cites W2031111076 @default.
• W2951048045 cites W2034824489 @default.
• W2951048045 cites W2037307492 @default.
• W2951048045 cites W2049806528 @default.
• W2951048045 cites W2050808516 @default.
• W2951048045 cites W2052783300 @default.
• W2951048045 cites W2059164249 @default.
• W2951048045 cites W2059223526 @default.
• W2951048045 cites W2071955212 @default.
• W2951048045 cites W2072420392 @default.
• W2951048045 cites W2074780489 @default.
• W2951048045 cites W2075845422 @default.
• W2951048045 cites W2081319561 @default.
• W2951048045 cites W2085109799 @default.
• W2951048045 cites W2087977249 @default.
• W2951048045 cites W2096240982 @default.
• W2951048045 cites W2116394679 @default.
• W2951048045 cites W2146596365 @default.
• W2951048045 cites W2149509906 @default.
• W2951048045 cites W2889775884 @default.
• W2951048045 cites W2894515191 @default.
• W2951048045 cites W34709307 @default.
• W2951048045 cites W4239724211 @default.
• W2951048045 doi "https://doi.org/10.1016/j.neuint.2019.104493" @default.
• W2951048045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31220473" @default.
• W2951048045 hasPublicationYear "2019" @default.
• W2951048045 type Work @default.
• W2951048045 sameAs 2951048045 @default.
• W2951048045 citedByCount "29" @default.
• W2951048045 countsByYear W29510480452020 @default.
• W2951048045 countsByYear W29510480452021 @default.
• W2951048045 countsByYear W29510480452022 @default.
• W2951048045 countsByYear W29510480452023 @default.
• W2951048045 crossrefType "journal-article" @default.
• W2951048045 hasAuthorship W2951048045A5008950662 @default.
• W2951048045 hasAuthorship W2951048045A5025148084 @default.
• W2951048045 hasAuthorship W2951048045A5039433631 @default.
• W2951048045 hasAuthorship W2951048045A5053129505 @default.
• W2951048045 hasAuthorship W2951048045A5074471869 @default.
• W2951048045 hasAuthorship W2951048045A5082629853 @default.
• W2951048045 hasConcept C126322002 @default.
• W2951048045 hasConcept C134018914 @default.
• W2951048045 hasConcept C169760540 @default.
• W2951048045 hasConcept C170493617 @default.
• W2951048045 hasConcept C185592680 @default.
• W2951048045 hasConcept C25498285 @default.
• W2951048045 hasConcept C2776108384 @default.
• W2951048045 hasConcept C2776814716 @default.
• W2951048045 hasConcept C2778938600 @default.
• W2951048045 hasConcept C2780648746 @default.
• W2951048045 hasConcept C2781012912 @default.
• W2951048045 hasConcept C2781161787 @default.
• W2951048045 hasConcept C2781302539 @default.
• W2951048045 hasConcept C42219234 @default.
• W2951048045 hasConcept C61174792 @default.
• W2951048045 hasConcept C71924100 @default.
• W2951048045 hasConcept C86803240 @default.
• W2951048045 hasConcept C98274493 @default.
• W2951048045 hasConceptScore W2951048045C126322002 @default.
• W2951048045 hasConceptScore W2951048045C134018914 @default.
• W2951048045 hasConceptScore W2951048045C169760540 @default.
• W2951048045 hasConceptScore W2951048045C170493617 @default.
• W2951048045 hasConceptScore W2951048045C185592680 @default.
• W2951048045 hasConceptScore W2951048045C25498285 @default.
• W2951048045 hasConceptScore W2951048045C2776108384 @default.
• W2951048045 hasConceptScore W2951048045C2776814716 @default.
• W2951048045 hasConceptScore W2951048045C2778938600 @default.
• W2951048045 hasConceptScore W2951048045C2780648746 @default.
• W2951048045 hasConceptScore W2951048045C2781012912 @default.
• W2951048045 hasConceptScore W2951048045C2781161787 @default.
• W2951048045 hasConceptScore W2951048045C2781302539 @default.

• next