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- W2951072147 abstract "Epstein-Barr virus (EBV) successfully persists in the vast majority of adults but causes lymphoid and epithelial malignancies in a small fraction of latently infected individuals. Innate immunity is the first-line antiviral defense, which EBV has to evade in favor of its own replication and infection. EBV uses multiple strategies to perturb innate immune signaling pathways activated by Toll-like, RIG-I-like, NOD-like, and AIM2-like receptors as well as cyclic GMP-AMP synthase. EBV also counteracts interferon production and signaling, including TBK1-IRF3 and JAK-STAT pathways. However, activation of innate immunity also triggers pro-inflammatory response and proteolytic cleavage of caspases, both of which exhibit proviral activity under some circumstances. Pathogenic inflammation also contributes to EBV oncogenesis. EBV activates NFκB signaling and induces pro-inflammatory cytokines. Through differential modulation of the proviral and antiviral roles of caspases and other host factors at different stages of infection, EBV usurps cellular programs for death and inflammation to its own benefits. The outcome of EBV infection is governed by a delicate interplay between innate immunity and EBV. A better understanding of this interplay will instruct prevention and intervention of EBV-associated cancers." @default.
- W2951072147 created "2019-06-27" @default.
- W2951072147 creator A5008416614 @default.
- W2951072147 creator A5038876168 @default.
- W2951072147 creator A5048329643 @default.
- W2951072147 creator A5060375881 @default.
- W2951072147 date "2019-06-24" @default.
- W2951072147 modified "2023-10-01" @default.
- W2951072147 title "Epstein–Barr Virus and Innate Immunity: Friends or Foes?" @default.
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