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- W2951078889 abstract "Nonclassical platinum-based antitumor agents have shown enormous potential in the treatment of chemoresistant cancers. The design of these agents is based on the hypothesis that platinum-containing pharmacophores that react with nuclear DNA in cancer cells radically differently than the clinical agent cisplatin will produce a unique spectrum of biological activity. One such class of molecules are platinum-acridine hybrid agents derived from the prototypical complex [PtCl(en)(ACRAMTU)](NO(3))(2), en = ethane-1,2-diamine, ACRAMTU = 1-[2-(acridin-9-ylamino)ethyl]-1,3-dimethylthiourea (PT-ACRAMTU). This article summarizes milestones in the development of these agents and reviews critical key concepts that have guided their design and that of related compounds." @default.
- W2951078889 created "2019-06-27" @default.
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- W2951078889 date "2013-02-19" @default.
- W2951078889 modified "2023-09-27" @default.
- W2951078889 title "ChemInform Abstract: DNA Metalating-Intercalating Hybrid Agents for the Treatment of Chemoresistant Cancers" @default.
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- W2951078889 doi "https://doi.org/10.1002/chin.201308189" @default.
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