FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951091567> ?p ?o ?g. }

• W2951091567 abstract "Understanding gene regulation is a fundamental step towards understanding of how cells function and respond to environmental cues and perturbations. An important step in this direction is to infer the transcription factor-gene regulatory network (GRN). However gene regulatory networks are typically constructed disregarding the fact that regulatory programs are conditioned on tissue type, developmental stage, sex, and other factors. Collecting multitude of features required for a reliable construction of GRNs such as physical features and functional features for every context of interest is costly. Therefore we need methods that is able to use the knowledge of a context-agnostic network for construction of a context specific regulatory network. To address this challenge we developed a computational approach that uses context specific expression data and a GRN constructed in a different but related context to construct a context specific GRN. Our method, NetREX, is inspired by network component analysis that estimates TF activities and their influences on target genes given predetermined topology of a TF-gene network. To predict a network under a different condition, NetREX removes the restriction that the topology of the TF-gene network is fixed and allows for adding and removing edges to that network. To solve the corresponding optimization problem, we provide a general mathematical framework allowing use of the recently proposed PALM technique and develop a convergent algorithm. We tested our NetREX on simulated data and subsequently applied it to gene expression data in adult females from Drosophila deletion (DrosDel) panel. The networks predicted by NetREX showed higher biological consistency than alternative approaches. In addition, we used the list of recently identified targets of the Doublesex (DSX) transcription factor to demonstrate the predictive power of our method." @default.
• W2951091567 created "2019-06-27" @default.
• W2951091567 creator A5007649502 @default.
• W2951091567 creator A5027637320 @default.
• W2951091567 creator A5045346418 @default.
• W2951091567 creator A5066462727 @default.
• W2951091567 creator A5069698488 @default.
• W2951091567 creator A5089548776 @default.
• W2951091567 date "2017-04-18" @default.
• W2951091567 modified "2023-09-27" @default.
• W2951091567 title "NetREX: Network Rewiring using EXpression - Towards Context Specific Regulatory Networks" @default.
• W2951091567 cites W1490161904 @default.
• W2951091567 cites W1981409633 @default.
• W2951091567 cites W1996332055 @default.
• W2951091567 cites W2011426324 @default.
• W2951091567 cites W2017209997 @default.
• W2951091567 cites W2027982384 @default.
• W2951091567 cites W2069645361 @default.
• W2951091567 cites W2076513103 @default.
• W2951091567 cites W2082639035 @default.
• W2951091567 cites W2085454841 @default.
• W2951091567 cites W2086103112 @default.
• W2951091567 cites W2105282404 @default.
• W2951091567 cites W2122825543 @default.
• W2951091567 cites W2129614684 @default.
• W2951091567 cites W2131413501 @default.
• W2951091567 cites W2144359569 @default.
• W2951091567 cites W2144738674 @default.
• W2951091567 cites W2147440110 @default.
• W2951091567 cites W2150547367 @default.
• W2951091567 cites W2151038079 @default.
• W2951091567 cites W2237142366 @default.
• W2951091567 cites W2913535645 @default.
• W2951091567 doi "https://doi.org/10.48550/arxiv.1704.05343" @default.
• W2951091567 hasPublicationYear "2017" @default.
• W2951091567 type Work @default.
• W2951091567 sameAs 2951091567 @default.
• W2951091567 citedByCount "0" @default.
• W2951091567 crossrefType "posted-content" @default.
• W2951091567 hasAuthorship W2951091567A5007649502 @default.
• W2951091567 hasAuthorship W2951091567A5027637320 @default.
• W2951091567 hasAuthorship W2951091567A5045346418 @default.
• W2951091567 hasAuthorship W2951091567A5066462727 @default.
• W2951091567 hasAuthorship W2951091567A5069698488 @default.
• W2951091567 hasAuthorship W2951091567A5089548776 @default.
• W2951091567 hasBestOaLocation W29510915671 @default.
• W2951091567 hasConcept C104317684 @default.
• W2951091567 hasConcept C114614502 @default.
• W2951091567 hasConcept C14036430 @default.
• W2951091567 hasConcept C150194340 @default.
• W2951091567 hasConcept C151730666 @default.
• W2951091567 hasConcept C154945302 @default.
• W2951091567 hasConcept C184720557 @default.
• W2951091567 hasConcept C199845137 @default.
• W2951091567 hasConcept C2776436953 @default.
• W2951091567 hasConcept C2776514529 @default.
• W2951091567 hasConcept C2779343474 @default.
• W2951091567 hasConcept C28225019 @default.
• W2951091567 hasConcept C31258907 @default.
• W2951091567 hasConcept C33923547 @default.
• W2951091567 hasConcept C41008148 @default.
• W2951091567 hasConcept C54355233 @default.
• W2951091567 hasConcept C54458228 @default.
• W2951091567 hasConcept C67339327 @default.
• W2951091567 hasConcept C67705224 @default.
• W2951091567 hasConcept C70721500 @default.
• W2951091567 hasConcept C86803240 @default.
• W2951091567 hasConceptScore W2951091567C104317684 @default.
• W2951091567 hasConceptScore W2951091567C114614502 @default.
• W2951091567 hasConceptScore W2951091567C14036430 @default.
• W2951091567 hasConceptScore W2951091567C150194340 @default.
• W2951091567 hasConceptScore W2951091567C151730666 @default.
• W2951091567 hasConceptScore W2951091567C154945302 @default.
• W2951091567 hasConceptScore W2951091567C184720557 @default.
• W2951091567 hasConceptScore W2951091567C199845137 @default.
• W2951091567 hasConceptScore W2951091567C2776436953 @default.
• W2951091567 hasConceptScore W2951091567C2776514529 @default.
• W2951091567 hasConceptScore W2951091567C2779343474 @default.
• W2951091567 hasConceptScore W2951091567C28225019 @default.
• W2951091567 hasConceptScore W2951091567C31258907 @default.
• W2951091567 hasConceptScore W2951091567C33923547 @default.
• W2951091567 hasConceptScore W2951091567C41008148 @default.
• W2951091567 hasConceptScore W2951091567C54355233 @default.
• W2951091567 hasConceptScore W2951091567C54458228 @default.
• W2951091567 hasConceptScore W2951091567C67339327 @default.
• W2951091567 hasConceptScore W2951091567C67705224 @default.
• W2951091567 hasConceptScore W2951091567C70721500 @default.
• W2951091567 hasConceptScore W2951091567C86803240 @default.
• W2951091567 hasLocation W29510915671 @default.
• W2951091567 hasLocation W29510915672 @default.
• W2951091567 hasOpenAccess W2951091567 @default.
• W2951091567 hasPrimaryLocation W29510915671 @default.
• W2951091567 hasRelatedWork W1547016179 @default.
• W2951091567 hasRelatedWork W2059430635 @default.
• W2951091567 hasRelatedWork W2067266657 @default.
• W2951091567 hasRelatedWork W2101770419 @default.
• W2951091567 hasRelatedWork W2114466827 @default.
• W2951091567 hasRelatedWork W2145198449 @default.
• W2951091567 hasRelatedWork W2548423198 @default.
• W2951091567 hasRelatedWork W3165870816 @default.

• next