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- W2951128431 abstract "Steroid sulfatase (STS) plays a momentous role in the conversion of sulfated steroids, which are biologically inactive, into biologically active un-sulfated steroid hormones, which support the development and growth of a number of hormone-dependent cancers, including breast cancer. Therefore, inhibitors of STS are supposed to be potential drugs for the treatment of breast and other steroid-dependent cancers. The present review concentrates on broad chemical classification of steroid sulfatase inhibitors. The inhibitors reviewed are classified into four main categories: Steroid sulfamate based inhibitors; Steroid non-sulfamate based inhibitors; Non-steroidal sulfamate based inhibitors; Non-steroidal non-sulfamate based inhibitors. A succinct overview of current treatment of cancer, estradiol precursors, STS enzyme and its role in breast cancer is herein described." @default.
- W2951128431 created "2019-06-27" @default.
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- W2951128431 date "2016-05-01" @default.
- W2951128431 modified "2023-09-27" @default.
- W2951128431 title "ChemInform Abstract: Sulfatase Inhibitors for Recidivist Breast Cancer Treatment: A Chemical Review" @default.
- W2951128431 cites W2280153690 @default.
- W2951128431 doi "https://doi.org/10.1002/chin.201622263" @default.
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