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- W2951130131 endingPage "613" @default.
- W2951130131 startingPage "585" @default.
- W2951130131 abstract "Hydrogels are polymer networks that are crosslinked. They have high affinity for water due to the presence of great number of hydrophilic groups and are prevented from dissolving due to their crosslinked chemical or physical bonds among the polymer chains, resulting in enormous swelling with high water-holding capacity. This property is utilized to deliver vast number of diverse therapeutic molecules in a controlled manner. Use of the natural polymers as base materials, particularly polysaccharides as scaffold in hydrogels, was extensively explored. Their popularity in the hydrogel preparation is due to their easy availability in highly pure form and has the functional groups for further chemical modification. Beside these, polysaccharide-based hydrogels are biocompatible, low toxic, and biodegradable. The polysaccharide can be manipulated in such a way that they become sensitive to many environmental stimuli; thus, responsive hydrogel systems are developed to deliver the loaded therapeutics in a particular environment. In the same line, advanced development is to generate a polysaccharide hydrogel in situ thus eliminating surgical implantation. The development of smart drug-delivery systems based on polysaccharide-based hydrogels relies on thorough understanding of physical and chemical characteristics of polysaccharide-based hydrogels along with several other tunable variables in the process. This chapter describes the latest developments in the preparation of various polysaccharide-based hydrogels and their distinct drug-delivery applications." @default.
- W2951130131 created "2019-06-27" @default.
- W2951130131 creator A5068727523 @default.
- W2951130131 creator A5078514929 @default.
- W2951130131 date "2019-01-01" @default.
- W2951130131 modified "2023-10-18" @default.
- W2951130131 title "Biopolysaccharide-based hydrogel materials for drug delivery" @default.
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