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- W2951131311 abstract "A new class of inhibitors of HIV-1 reverse transcriptase obtained by the systematic structural simplification of epicatechin and epigallocatechin gallates are also shown here to inhibit DNA-strand-transfer, a process critical to the completion of the HIV-1-RT reproduction and to recombination-associated mutation of the virus. Up to 80-fold selectivity for DNA-strand-transfer inhibition over polymerase inhibition was observed for a defined subset of these agents. Such specific DNA-strand-transfer inhibitors may have important therapeutic potential." @default.
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- W2951131311 date "2010-05-21" @default.
- W2951131311 modified "2023-09-27" @default.
- W2951131311 title "ChemInform Abstract: Differential Inhibition of Polymerase and Strand-Transfer Activities of HIV-1 Reverse Transcriptase." @default.
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- W2951131311 doi "https://doi.org/10.1002/chin.200224242" @default.
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