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- W2951134233 abstract "The incidence of testicular cancer (TC) has a dis- tinct geographic distribution but is increasing in most coun- tries, including France. The most likely origin of TC is a lack of normal germ cell differentiation in the foetal testis. The maintained immature germ cells could proliferate after puberty to induce testicular tumor. Because of its frequent association with cryptorchidism and infertility, TC could be part of the testicular dysgenesis syndrome. The role of genetic factors is suggested by the frequency of familial TC cases, but no responsible gene has been clearly identified until now. Among the various studied genes, those regula- ting the KITLG/KIT pathway involved in primordial germ cell proliferation seem to play an important role. Studies made in immigrants and twins suggest the influence of environmental factors on the origin of TC. Hormonal dere- gulation occurring during prenatal life or puberty could facilitate the development of TC. However, the role of exo- genous substances acting as endocrine disruptors has not been demonstrated yet. To cite this journal: Andrologie 22 (2012)." @default.
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- W2951134233 date "2012-01-01" @default.
- W2951134233 modified "2023-09-26" @default.
- W2951134233 title "Le cancer du testicule : facteurs de risque génétiques et environnementaux Testicular cancer: genetic and environmental risk factors" @default.
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