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• W2951164539 abstract "A simple one-pot, two-step process for the conversion of 2-acylbenzoic acids to phthalazin-1(2H)-ones was developed. A robust process was required that delivered the final isolated solid with consistently low levels of residual hydrazine, for further processing to the final drug substance. An in situ formed intermediate was critical to control reactivity and allowed for the controlled crystallization that prevented entrainment of hydrazine. Leveraging Process Analytical Technology (PAT), we investigated the reaction profile with in situ IR and Power Compensation Calorimetry (PCC) to aid development prior to a successful scale-up." @default.
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• W2951164539 date "2015-06-25" @default.
• W2951164539 modified "2023-10-16" @default.
• W2951164539 title "Synthesis of 4-Substituted Phthalazin-1(2<i>H</i>)-ones from 2-Acylbenzoic Acids: Controlling Hydrazine in a Pharmaceutical Intermediate through PAT-Guided Process Development" @default.
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• W2951164539 doi "https://doi.org/10.1021/acs.oprd.5b00135" @default.
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