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• W2951188225 endingPage "24" @default.
• W2951188225 startingPage "10" @default.
• W2951188225 abstract "• 24 cyclic compounds were assessed for DNA reactivity in embryo-fetal chicken livers. • Unsubstituted compounds yielded negative results. • Most compounds with various substitutions produced DNA damage. • Substituted polycyclic compounds were more potent compared to monocyclic chemicals. • These finding support use of chicken egg model for structure-activity assessment. DNA-damaging activities of twenty-four structurally diverse unsubstituted and substituted cyclic compounds were assessed in embryo-fetal chicken livers. Formation of DNA adducts and strand breaks were measured using the nucleotide 32 P-postlabelling (NPL) and comet assays, respectively. Unsubstituted monocyclic benzene, polycyclic fused ring compound naphthalene, covalently connected polycyclic ring compound biphenyl, and heterocyclic ring compound fluorene did not produce DNA damage. Amino-substituted monocyclic compounds, aniline and p -phenylenediamine, as well as polycyclic 1-naphthylamine were also negative. In contrast, carcinogenic monocyclic methyl-substituted anilines: o -toluidine, 2,6-xylidine, 3,4-dimethylaniline, 4-chloro- o -toluidine; 2 methoxy-substituted methylaniline: p -cresidine; 2,4 and 2,6 diamino- or dinitro- substituted toluenes all produced DNA damage. Genotoxic polycyclic amino-substituted 2-naphthylamine, 4-aminobiphenyl, benzidine, methyl-substituted 3,2′-dimethyl-4-aminobiphenyl and 4-dimethylaminoazobenzene as well as amino- and nitro- fluorenes substituted at the 1 or 2 positions also were positive in at least one of the assays. Overall, the DNA damaging activity of cyclic compounds in embryo-fetal chicken livers reflected the type and position of the substitution on the aromatic ring. Additionally, substituted polycyclic compounds exhibited higher DNA-damaging potency compared to monocyclic chemicals. These results are congruent with in vivo findings in other species, establishing chicken eggs as a reliable system for structure-activity assessment of members of groups of related chemicals." @default.
• W2951188225 created "2019-06-27" @default.
• W2951188225 creator A5011954862 @default.
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• W2951188225 date "2019-08-01" @default.
• W2951188225 modified "2023-09-29" @default.
• W2951188225 title "DNA-damaging activities of twenty-four structurally diverse unsubstituted and substituted cyclic compounds in embryo-fetal chicken livers" @default.
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• W2951188225 doi "https://doi.org/10.1016/j.mrgentox.2019.06.004" @default.
• W2951188225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31326031" @default.
• W2951188225 hasPublicationYear "2019" @default.
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