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- W2951217748 abstract "Abstract A series of compounds, directed by the Topliss Operational Scheme, were synthesized and evaluated to investigate structure activity relationships of the N -benzoyl moiety of taxol. Evaluation of the newly prepared derivatives in the microtubule assembly assay and for cytotoxicity revealed that they possessed biological properties similar to taxol. Nine novel substituted N -benzoyl analogues of taxol were prepared, using the Topliss approach to drug design. The taxanes were prepared from N -acyl-3-hydroxy-4-phenyl-2-azetidinones and baccatin III or by acylation of N -debenzoyltaxol. In vitro biological evaluation revealed that these analogues had activity similar to taxol." @default.
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- W2951217748 date "2010-08-18" @default.
- W2951217748 modified "2023-09-26" @default.
- W2951217748 title "ChemInform Abstract: Topliss Approach to the Synthesis of Biologically Active Substituted N- Benzoyl Taxol Analogues." @default.
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- W2951217748 doi "https://doi.org/10.1002/chin.199506248" @default.
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