FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951228711> ?p ?o ?g. }

• W2951228711 endingPage "10088" @default.
• W2951228711 startingPage "10078" @default.
• W2951228711 abstract "While a wide range of experimental and commercial transfection reagents are currently available, persistent problems remain regarding their suitability for continued development. These include the transfection efficiency for difficult-to-transfect cell types and the risks of decreased cell viability that may arise from any transfection that does occur. Therefore, research is now turning toward alternative molecules that improve the toxicity profile of the gene delivery vector (GDV), while maintaining the transfection efficiency. Among them, cell-penetrating peptides, such as octa-arginine, have shown significant potential as GDVs. Their pharmacokinetic and pharmacodynamic properties can be enhanced through peptidomimetic conversion, whereby a peptide is modified into a synthetic analogue that mimics its structure and/or function, but whose backbone is not solely based on α-amino acids. Using this technology, novel peptidomimetics were developed by co- and postpolymerization functionalization of substituted ethylene oxides, producing poly(ethylene glycol) (PEG)-based peptidomimetics termed PEGtides. Specifically, a PEGtide of the poly(α-amino acid) oligo-arginine [poly(glycidylguanidine)] was assessed for its ability to complex and deliver a small interfering ribonucleic acid (siRNA) using a range of cell assays and high-content analysis. PEGtide-siRNA demonstrated significantly increased internalization and gene inhibition over 24 h in Calu-3 pulmonary epithelial cells compared to commercial controls and octa-arginine-treated samples, with no evidence of toxicity. Furthermore, PEGtide-siRNA nanocomplexes can provide significant levels of gene inhibition in difficult-to-transfect mouse embryonic hypothalamic (mHypo N41) cells. Overall, the usefulness of this novel PEGtide for gene delivery was clearly demonstrated, establishing it as a promising candidate for continued translational research." @default.
• W2951228711 created "2019-06-27" @default.
• W2951228711 creator A5016332855 @default.
• W2951228711 creator A5022625999 @default.
• W2951228711 creator A5042774342 @default.
• W2951228711 creator A5064641182 @default.
• W2951228711 creator A5078087258 @default.
• W2951228711 creator A5078518166 @default.
• W2951228711 creator A5088801371 @default.
• W2951228711 creator A5089330086 @default.
• W2951228711 date "2019-06-10" @default.
• W2951228711 modified "2023-10-18" @default.
• W2951228711 title "Poly(ethylene glycol)-Based Peptidomimetic “PEGtide” of Oligo-Arginine Allows for Efficient siRNA Transfection and Gene Inhibition" @default.
• W2951228711 cites W1808439685 @default.
• W2951228711 cites W1964580701 @default.
• W2951228711 cites W1967170977 @default.
• W2951228711 cites W1975875150 @default.
• W2951228711 cites W1978643345 @default.
• W2951228711 cites W1983902360 @default.
• W2951228711 cites W1985321010 @default.
• W2951228711 cites W1985469208 @default.
• W2951228711 cites W1989576298 @default.
• W2951228711 cites W1990264812 @default.
• W2951228711 cites W1992044364 @default.
• W2951228711 cites W1992265395 @default.
• W2951228711 cites W2007999194 @default.
• W2951228711 cites W2008568654 @default.
• W2951228711 cites W2022234371 @default.
• W2951228711 cites W2022310108 @default.
• W2951228711 cites W2022434323 @default.
• W2951228711 cites W2027876233 @default.
• W2951228711 cites W2038803695 @default.
• W2951228711 cites W2044696917 @default.
• W2951228711 cites W2046686046 @default.
• W2951228711 cites W2050485122 @default.
• W2951228711 cites W2055636402 @default.
• W2951228711 cites W2059262359 @default.
• W2951228711 cites W2060945669 @default.
• W2951228711 cites W2065705015 @default.
• W2951228711 cites W2067522447 @default.
• W2951228711 cites W2075592400 @default.
• W2951228711 cites W2075663982 @default.
• W2951228711 cites W2075710148 @default.
• W2951228711 cites W2086272849 @default.
• W2951228711 cites W2090458301 @default.
• W2951228711 cites W2090480642 @default.
• W2951228711 cites W2092817859 @default.
• W2951228711 cites W2108371149 @default.
• W2951228711 cites W2111994795 @default.
• W2951228711 cites W2117150402 @default.
• W2951228711 cites W2120820989 @default.
• W2951228711 cites W2138509357 @default.
• W2951228711 cites W2150632052 @default.
• W2951228711 cites W2155239981 @default.
• W2951228711 cites W2157979200 @default.
• W2951228711 cites W2164641603 @default.
• W2951228711 cites W2209408609 @default.
• W2951228711 cites W2251045241 @default.
• W2951228711 cites W2255664554 @default.
• W2951228711 cites W2414834011 @default.
• W2951228711 cites W2520736447 @default.
• W2951228711 cites W2556148213 @default.
• W2951228711 cites W2568633826 @default.
• W2951228711 cites W2593832193 @default.
• W2951228711 cites W2600042835 @default.
• W2951228711 cites W2620241325 @default.
• W2951228711 cites W2739354616 @default.
• W2951228711 cites W2800938802 @default.
• W2951228711 cites W4249183479 @default.
• W2951228711 cites W4253658821 @default.
• W2951228711 cites W47706997 @default.
• W2951228711 doi "https://doi.org/10.1021/acsomega.9b00265" @default.
• W2951228711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6647993" @default.
• W2951228711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31460100" @default.
• W2951228711 hasPublicationYear "2019" @default.
• W2951228711 type Work @default.
• W2951228711 sameAs 2951228711 @default.
• W2951228711 citedByCount "9" @default.
• W2951228711 countsByYear W29512287112019 @default.
• W2951228711 countsByYear W29512287112020 @default.
• W2951228711 countsByYear W29512287112021 @default.
• W2951228711 countsByYear W29512287112022 @default.
• W2951228711 countsByYear W29512287112023 @default.
• W2951228711 crossrefType "journal-article" @default.
• W2951228711 hasAuthorship W2951228711A5016332855 @default.
• W2951228711 hasAuthorship W2951228711A5022625999 @default.
• W2951228711 hasAuthorship W2951228711A5042774342 @default.
• W2951228711 hasAuthorship W2951228711A5064641182 @default.
• W2951228711 hasAuthorship W2951228711A5078087258 @default.
• W2951228711 hasAuthorship W2951228711A5078518166 @default.
• W2951228711 hasAuthorship W2951228711A5088801371 @default.
• W2951228711 hasAuthorship W2951228711A5089330086 @default.
• W2951228711 hasBestOaLocation W29512287111 @default.
• W2951228711 hasConcept C104317684 @default.
• W2951228711 hasConcept C124790011 @default.
• W2951228711 hasConcept C12554922 @default.
• W2951228711 hasConcept C135983454 @default.
• W2951228711 hasConcept C153911025 @default.

• next