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- W2951246160 abstract "Insula dysfunction contributes to nicotine use disorders. Yet, much remains unknown about how insular functions promote nicotine use. We review current models of brain networks in smoking and propose an extension to those models that emphasizes the role of the insula in craving. During acute withdrawal, the insula provides the sensation of craving to the cerebrum and is thought to negotiate craving sensations with cognitive control to guide behavior – either to smoke or abstain. Recent studies have shown that insula processing is saturable, such that different insular functions compete for limited resources. We propose that this saturability explains how craving during withdrawal can overload insular processing to the exclusion of other functions, such as saliency and network homeostasis. A novel signal flow model illustrates how limited insular capacity leads to breakdown of normal function. Finally, we discuss suitability of insula as a neuromodulation target to promote cessation. Given the limited efficacy of standard-of-care treatments for nicotine use disorder, insular neuromodulation offers an innovative, potentially therapeutic target for improving smoking cessation." @default.
- W2951246160 created "2019-06-27" @default.
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- W2951246160 date "2019-08-01" @default.
- W2951246160 modified "2023-10-17" @default.
- W2951246160 title "The insula in nicotine use disorder: Functional neuroimaging and implications for neuromodulation" @default.
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- W2951246160 cites W1968161699 @default.
- W2951246160 cites W1977119744 @default.
- W2951246160 cites W1986315432 @default.
- W2951246160 cites W1991144875 @default.
- W2951246160 cites W1991656721 @default.
- W2951246160 cites W1995634947 @default.
- W2951246160 cites W1995875735 @default.
- W2951246160 cites W1996155736 @default.
- W2951246160 cites W2000268513 @default.
- W2951246160 cites W2005933475 @default.
- W2951246160 cites W2016954751 @default.
- W2951246160 cites W2019584635 @default.
- W2951246160 cites W2021986306 @default.
- W2951246160 cites W2022269431 @default.
- W2951246160 cites W2024284755 @default.
- W2951246160 cites W2024690874 @default.
- W2951246160 cites W2025887083 @default.
- W2951246160 cites W2028365182 @default.
- W2951246160 cites W2031250376 @default.
- W2951246160 cites W2031548929 @default.
- W2951246160 cites W2032030322 @default.
- W2951246160 cites W2035027501 @default.
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- W2951246160 doi "https://doi.org/10.1016/j.neubiorev.2019.06.002" @default.
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