Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951260481> ?p ?o ?g. }
- W2951260481 abstract "Abstract Chromatin loops enable transcription factor-bound distal enhancers to interact with their target promoters to regulate transcriptional programs. Although developmental transcription factors, such as active forms of Notch, can directly stimulate transcription by activating enhancers, the effect of their oncogenic subversion on the 3-dimensional (3D) organization of the cancer genome is largely undetermined. By mapping chromatin looping genome-wide in Notch-dependent triple-negative breast cancer and B-cell lymphoma, we show that far beyond the well-characterized role of Notch as an activator of distal enhancers, Notch regulates its direct target genes through establishing new long-range regulatory interactions. Moreover, a large fraction of Notch-promoted regulatory loops forms highly interacting enhancer and promoter spatial clusters, termed “3D cliques”. Loss-and gain-of-function experiments show that Notch preferentially targets hyperconnected 3D cliques that regulate the expression of crucial proto-oncogenes. Our observations suggest that oncogenic hijacking of developmental transcription factors can dysregulate transcription through widespread effects on the spatial organization of cancer genomes." @default.
- W2951260481 created "2019-06-27" @default.
- W2951260481 creator A5006492518 @default.
- W2951260481 creator A5010733473 @default.
- W2951260481 creator A5015441500 @default.
- W2951260481 creator A5019759834 @default.
- W2951260481 creator A5025796462 @default.
- W2951260481 creator A5028626404 @default.
- W2951260481 creator A5028743173 @default.
- W2951260481 creator A5029821721 @default.
- W2951260481 creator A5033488040 @default.
- W2951260481 creator A5036667046 @default.
- W2951260481 creator A5043117985 @default.
- W2951260481 creator A5043149847 @default.
- W2951260481 creator A5053973336 @default.
- W2951260481 creator A5057910100 @default.
- W2951260481 creator A5061205525 @default.
- W2951260481 creator A5072826979 @default.
- W2951260481 creator A5075667758 @default.
- W2951260481 creator A5089045622 @default.
- W2951260481 creator A5090689057 @default.
- W2951260481 date "2019-01-22" @default.
- W2951260481 modified "2023-09-28" @default.
- W2951260481 title "Oncogenic Notch promotes long-range regulatory interactions within hyperconnected 3D cliques" @default.
- W2951260481 cites W1565385417 @default.
- W2951260481 cites W1593805248 @default.
- W2951260481 cites W1601336165 @default.
- W2951260481 cites W1605145036 @default.
- W2951260481 cites W1831401007 @default.
- W2951260481 cites W1859117663 @default.
- W2951260481 cites W1970831058 @default.
- W2951260481 cites W1973062929 @default.
- W2951260481 cites W1975542854 @default.
- W2951260481 cites W1982875955 @default.
- W2951260481 cites W1982994560 @default.
- W2951260481 cites W1984365236 @default.
- W2951260481 cites W1987371782 @default.
- W2951260481 cites W1996258482 @default.
- W2951260481 cites W1997877243 @default.
- W2951260481 cites W2006806134 @default.
- W2951260481 cites W2008227324 @default.
- W2951260481 cites W2011463791 @default.
- W2951260481 cites W2012411473 @default.
- W2951260481 cites W2014787267 @default.
- W2951260481 cites W2018658338 @default.
- W2951260481 cites W2023297465 @default.
- W2951260481 cites W2028092386 @default.
- W2951260481 cites W2029492292 @default.
- W2951260481 cites W2043003064 @default.
- W2951260481 cites W2046085162 @default.
- W2951260481 cites W2047005748 @default.
- W2951260481 cites W2048263136 @default.
- W2951260481 cites W2051911149 @default.
- W2951260481 cites W2056103949 @default.
- W2951260481 cites W2056144970 @default.
- W2951260481 cites W2062336370 @default.
- W2951260481 cites W2064537118 @default.
- W2951260481 cites W2065006553 @default.
- W2951260481 cites W2067704394 @default.
- W2951260481 cites W2070021921 @default.
- W2951260481 cites W2075368572 @default.
- W2951260481 cites W2080477348 @default.
- W2951260481 cites W2085220509 @default.
- W2951260481 cites W2086677653 @default.
- W2951260481 cites W2088578081 @default.
- W2951260481 cites W2091517552 @default.
- W2951260481 cites W2091548199 @default.
- W2951260481 cites W2099835784 @default.
- W2951260481 cites W2102645961 @default.
- W2951260481 cites W2104198050 @default.
- W2951260481 cites W2114031931 @default.
- W2951260481 cites W2114866946 @default.
- W2951260481 cites W2123227077 @default.
- W2951260481 cites W2124145402 @default.
- W2951260481 cites W2131681506 @default.
- W2951260481 cites W2132089243 @default.
- W2951260481 cites W2132257972 @default.
- W2951260481 cites W2136824726 @default.
- W2951260481 cites W2147135997 @default.
- W2951260481 cites W2147373929 @default.
- W2951260481 cites W2148261329 @default.
- W2951260481 cites W2149454526 @default.
- W2951260481 cites W2150013979 @default.
- W2951260481 cites W2152144700 @default.
- W2951260481 cites W2152516668 @default.
- W2951260481 cites W2152531901 @default.
- W2951260481 cites W2154968323 @default.
- W2951260481 cites W2161212572 @default.
- W2951260481 cites W2163412235 @default.
- W2951260481 cites W2165833564 @default.
- W2951260481 cites W2166537866 @default.
- W2951260481 cites W2175853567 @default.
- W2951260481 cites W2185236314 @default.
- W2951260481 cites W2187435303 @default.
- W2951260481 cites W2192926654 @default.
- W2951260481 cites W2195190137 @default.
- W2951260481 cites W2222531233 @default.
- W2951260481 cites W2231928957 @default.
- W2951260481 cites W2259227992 @default.
- W2951260481 cites W2267962174 @default.