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- W2951265099 abstract "A ring-opened side product 3, formed during the reduction of a pyridinium precursor to the antiarrhythmic drug, encainide (2), was isolated. The structure of 3 was confirmed by an independent synthesis from o-iodonitrobenzene and 1-hepten-3-ol. The key step was a palladium(II) catalyzed coupling to introduce the 3-oxoheptyl side chain onto the aromatic ring. Synthetic 3 exhibited significant antiarrhythmic activity." @default.
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- W2951265099 date "1994-01-01" @default.
- W2951265099 modified "2023-10-09" @default.
- W2951265099 title "Synthesis of 4-Methoxy-<i>N</i>-{2-[3-(Methylamino)heptyl]phenyl}benzamide, an Antiarrhythmic Compound Related to Encainide" @default.
- W2951265099 doi "https://doi.org/10.1055/s-1994-25615" @default.
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