FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951269739> ?p ?o ?g. }

• W2951269739 endingPage "10" @default.
• W2951269739 startingPage "1" @default.
• W2951269739 abstract "An excessive pulmonary inflammatory response could explain the poor prognosis of chronic obstructive pulmonary disease (COPD) patients submitted to invasive mechanical ventilation. The aim of this study was to evaluate the response to normal tidal volume mechanical ventilation in an elastase-induced murine model of pulmonary emphysema. In this model, two time points, associated with different levels of lung inflammation but similar lung destruction, were analyzed. C57BL/6 mice received a tracheal instillation of 5 IU of porcine pancreatic elastase (Elastase mice) or the same volume of saline (Saline mice). Fourteen (D14) and 21 (D21) days after instillation, mice were anesthetized, intubated, and either mechanically ventilated (MV) or maintained on spontaneous ventilation (SV) during two hours. As compared with Saline mice, Elastase mice showed a similarly increased mean chord length and pulmonary compliance at D14 and D21, while bronchoalveolar lavage cellularity was comparable between groups. Lung mechanics was similarly altered during mechanical ventilation in Elastase and Saline mice. Activated alveolar macrophages CD11b mid were present in lung parenchyma in both Elastase SV mice and Elastase MV mice at D14 but were absent at D21 and in Saline mice, indicating an inflammatory state with elastase at D14 only. At D14, Elastase MV mice showed a significant increase in percentage of neutrophils in total lung, as compared with Elastase SV mice. Furthermore, alveolar macrophages of Elastase MV mice at D14 overexpressed Gr1, and monocytes showed a trend to overexpression of CD62L, compared with Elastase SV mice. In an elastase-induced model of pulmonary emphysema, normal tidal volume mechanical ventilation may produce an increase in the proportion of pulmonary neutrophils, and an activation of alveolar macrophages and pulmonary monocytes. This response seems to be observed only when the emphysema model shows an underlying inflammation (D14), reflected by the presence of activated alveolar macrophages CD11b mid." @default.
• W2951269739 created "2019-06-27" @default.
• W2951269739 creator A5022201858 @default.
• W2951269739 creator A5027038780 @default.
• W2951269739 creator A5027904428 @default.
• W2951269739 creator A5034421255 @default.
• W2951269739 creator A5042213559 @default.
• W2951269739 creator A5042987943 @default.
• W2951269739 creator A5046135818 @default.
• W2951269739 creator A5054386308 @default.
• W2951269739 creator A5062306514 @default.
• W2951269739 creator A5073173280 @default.
• W2951269739 date "2018-12-19" @default.
• W2951269739 modified "2023-10-18" @default.
• W2951269739 title "Inflammatory Cellular Response to Mechanical Ventilation in Elastase-Induced Experimental Emphysema: Role of Preexisting Alveolar Macrophages Infiltration" @default.
• W2951269739 cites W1221909616 @default.
• W2951269739 cites W1712140759 @default.
• W2951269739 cites W1899080772 @default.
• W2951269739 cites W1992702474 @default.
• W2951269739 cites W2001390836 @default.
• W2951269739 cites W2009816405 @default.
• W2951269739 cites W2019517485 @default.
• W2951269739 cites W2029109883 @default.
• W2951269739 cites W2052533687 @default.
• W2951269739 cites W2071938049 @default.
• W2951269739 cites W2076810949 @default.
• W2951269739 cites W2095677734 @default.
• W2951269739 cites W2098649952 @default.
• W2951269739 cites W2105216609 @default.
• W2951269739 cites W2105746446 @default.
• W2951269739 cites W2111097284 @default.
• W2951269739 cites W2112915641 @default.
• W2951269739 cites W2116244832 @default.
• W2951269739 cites W2118800567 @default.
• W2951269739 cites W2119301960 @default.
• W2951269739 cites W2120550838 @default.
• W2951269739 cites W2123014037 @default.
• W2951269739 cites W2125828034 @default.
• W2951269739 cites W2127951128 @default.
• W2951269739 cites W2132162009 @default.
• W2951269739 cites W2142401382 @default.
• W2951269739 cites W2142513442 @default.
• W2951269739 cites W2143500103 @default.
• W2951269739 cites W2147488335 @default.
• W2951269739 cites W2152547415 @default.
• W2951269739 cites W2162246648 @default.
• W2951269739 cites W2537606278 @default.
• W2951269739 cites W2597070792 @default.
• W2951269739 cites W2625702801 @default.
• W2951269739 cites W2741162779 @default.
• W2951269739 cites W39284671 @default.
• W2951269739 cites W4242936792 @default.
• W2951269739 doi "https://doi.org/10.1155/2018/5721293" @default.
• W2951269739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6313972" @default.
• W2951269739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30662910" @default.
• W2951269739 hasPublicationYear "2018" @default.
• W2951269739 type Work @default.
• W2951269739 sameAs 2951269739 @default.
• W2951269739 citedByCount "2" @default.
• W2951269739 countsByYear W29512697392021 @default.
• W2951269739 countsByYear W29512697392023 @default.
• W2951269739 crossrefType "journal-article" @default.
• W2951269739 hasAuthorship W2951269739A5022201858 @default.
• W2951269739 hasAuthorship W2951269739A5027038780 @default.
• W2951269739 hasAuthorship W2951269739A5027904428 @default.
• W2951269739 hasAuthorship W2951269739A5034421255 @default.
• W2951269739 hasAuthorship W2951269739A5042213559 @default.
• W2951269739 hasAuthorship W2951269739A5042987943 @default.
• W2951269739 hasAuthorship W2951269739A5046135818 @default.
• W2951269739 hasAuthorship W2951269739A5054386308 @default.
• W2951269739 hasAuthorship W2951269739A5062306514 @default.
• W2951269739 hasAuthorship W2951269739A5073173280 @default.
• W2951269739 hasBestOaLocation W29512697391 @default.
• W2951269739 hasConcept C126322002 @default.
• W2951269739 hasConcept C134018914 @default.
• W2951269739 hasConcept C142724271 @default.
• W2951269739 hasConcept C181199279 @default.
• W2951269739 hasConcept C185592680 @default.
• W2951269739 hasConcept C196822366 @default.
• W2951269739 hasConcept C203014093 @default.
• W2951269739 hasConcept C2776326425 @default.
• W2951269739 hasConcept C2776780178 @default.
• W2951269739 hasConcept C2776914184 @default.
• W2951269739 hasConcept C2777080012 @default.
• W2951269739 hasConcept C2777257755 @default.
• W2951269739 hasConcept C2777397205 @default.
• W2951269739 hasConcept C2777714996 @default.
• W2951269739 hasConcept C2777961210 @default.
• W2951269739 hasConcept C2781044401 @default.
• W2951269739 hasConcept C534529494 @default.
• W2951269739 hasConcept C55493867 @default.
• W2951269739 hasConcept C71924100 @default.
• W2951269739 hasConceptScore W2951269739C126322002 @default.
• W2951269739 hasConceptScore W2951269739C134018914 @default.
• W2951269739 hasConceptScore W2951269739C142724271 @default.
• W2951269739 hasConceptScore W2951269739C181199279 @default.
• W2951269739 hasConceptScore W2951269739C185592680 @default.
• W2951269739 hasConceptScore W2951269739C196822366 @default.

• next